Current development of β-carboline derived potential antimalarial scaffolds

Abstract

β-Carboline alkaloids are an eminent class of nitrogen-based natural alkaloids and therapeutic molecules which exert various pharmacological activities through diverse mechanisms. A lot of attention has recently been directed towards this moiety in order to develop effective antimalarial drugs. "Malaria", an acute febrile illness caused by diverse Plasmodium parasites, is a continuing and escalating problem that devastates economically less developed countries by significantly increased morbidity and mortality rates. The mounting parasite resistance towards the antimalarial drugs and augmenting the 'habitat of the insect vector' are creating a catastrophe, indicating an urgent need for new efficacious therapeutics to combat this tropical disease. This article comprehensively encapsulates the clinical and preclinical antimalarial scaffolds comprising β-carboline moiety in their structure. Herein, various classes of natural and semi-synthetic analogues of β-carbolines reported in the last decade (2011-2021) have been extensively studied and illustrated. This review will help the readers to develop an insight into the β-carboline based antimalarials and molecular mechanisms lying behind their mode of action, which is anticipated to be beneficial for the future development of new β-carboline based therapeutics.

Keywords: Alkaloids; Antimalarial; Antiplasmodial; Malaria; Plasmodium; Plasmodium falciparum; Plasmodium vivax; Resistance; β-carboline.