doi: 10.7164/antibiotics.40.1475.
Okilactomycin, a novel antibiotic produced by a Streptomyces species. I. Taxonomy, fermentation, isolation and characterization
Affiliations
- PMID: 3693116
- DOI: 10.7164/antibiotics.40.1475
Item in Clipboard
Okilactomycin, a novel antibiotic produced by a Streptomyces species. I. Taxonomy, fermentation, isolation and characterization
J Antibiot (Tokyo).
1987 Nov.
Free article
Abstract
Okilactomycin, a novel antibiotic, was isolated from the culture filtrate of a strain of actinomycetes. The producing organism, strain YP-02908L, was identified as Streptomyces griseoflavus subsp. zamamiensis subsp. nov. The antibiotic was extracted with ethyl acetate and purified by silica gel column chromatography. It was obtained as colorless prisms from a dichloromethane solution. It exhibited weak antimicrobial activity against Ehrlich ascites carcinoma in vivo. The apparent molecular formula of okilactomycin was determined as C24H32O6. It is a new member of the lactone group antibiotics.
Similar articles
-
Okilactomycin, a novel antibiotic produced by a Streptomyces species. II. Structure determination.J Antibiot (Tokyo). 1987 Nov;40(11):1483-9. doi: 10.7164/antibiotics.40.1483. J Antibiot (Tokyo). 1987. PMID: 3693117
-
Crisamicin A, a new antibiotic from Micromonospora. I. Taxonomy of the producing strain, fermentation, isolation, physico-chemical characterization and antimicrobial properties.J Antibiot (Tokyo). 1986 Mar;39(3):335-44. doi: 10.7164/antibiotics.39.335. J Antibiot (Tokyo). 1986. PMID: 3754547
-
Capuramycin, a new nucleoside antibiotic. Taxonomy, fermentation, isolation and characterization.J Antibiot (Tokyo). 1986 Aug;39(8):1047-53. doi: 10.7164/antibiotics.39.1047. J Antibiot (Tokyo). 1986. PMID: 3759655
-
Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties.J Antibiot (Tokyo). 1980 Oct;33(10):1120-7. doi: 10.7164/antibiotics.33.1120. J Antibiot (Tokyo). 1980. PMID: 7451362
-
Lavendomycin, a new antibiotic. I. Taxonomy, isolation and characterization.J Antibiot (Tokyo). 1985 Jun;38(6):691-8. doi: 10.7164/antibiotics.38.691. J Antibiot (Tokyo). 1985. PMID: 3839501
Cited by
-
Evolution of the total synthesis of (-)-okilactomycin exploiting a tandem oxy-cope rearrangement/oxidation, a Petasis-Ferrier union/rearrangement, and ring-closing metathesis.J Am Chem Soc. 2009 Feb 18;131(6):2348-58. doi: 10.1021/ja8084669. J Am Chem Soc. 2009. PMID: 19170499 Free PMC article.
-
Pyranone natural products as inspirations for catalytic reaction discovery and development.Acc Chem Res. 2015 Apr 21;48(4):1172-83. doi: 10.1021/ar5004576. Epub 2015 Mar 6. Acc Chem Res. 2015. PMID: 25742935 Free PMC article.
-
Stereoselective Synthesis and Anticancer Activity of 2,6-Disubstituted trans-3-Methylidenetetrahydropyran-4-ones.Materials (Basel). 2022 Apr 21;15(9):3030. doi: 10.3390/ma15093030. Materials (Basel). 2022. PMID: 35591364 Free PMC article.
-
Synthesis of (-)-okilactomycin by a Prins-type fragment-assembly strategy.Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5892-5. doi: 10.1002/anie.201102037. Epub 2011 May 10. Angew Chem Int Ed Engl. 2011. PMID: 21560215 Free PMC article. No abstract available.
-
Spirotetronate polyketides as leads in drug discovery.J Nat Prod. 2015 Mar 27;78(3):562-75. doi: 10.1021/np500757w. Epub 2014 Dec 1. J Nat Prod. 2015. PMID: 25434976 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
