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. 2023 Mar 16;186(6):1101-1102.
doi: 10.1016/j.cell.2023.01.024.

Cord blood grafts for patients with HIV?

Andromachi Scaradavou  1
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Cord blood grafts for patients with HIV?

Andromachi Scaradavou. Cell. .
Free article

Abstract

Since CCR5 is a key co-receptor for HIV entry into cells, replacing an HIV patient's cells with CCR5-deficient cells is thought to protect the new hematopoietic/immune system from infection. In this issue of Cell, Hsu et al. show that transplanting a cord blood graft carrying the CCR5Δ32 mutation led to a durable HIV remission in a patient with HIV and leukemia.

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  • HIV-1 remission and possible cure in a woman after haplo-cord blood transplant.
    Hsu J, Van Besien K, Glesby MJ, Pahwa S, Coletti A, Warshaw MG, Petz L, Moore TB, Chen YH, Pallikkuth S, Dhummakupt A, Cortado R, Golner A, Bone F, Baldo M, Riches M, Mellors JW, Tobin NH, Browning R, Persaud D, Bryson Y; International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1107 Team. Hsu J, et al. Cell. 2023 Mar 16;186(6):1115-1126.e8. doi: 10.1016/j.cell.2023.02.030. Cell. 2023. PMID: 36931242 Free PMC article.

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