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Comment
. 2023 Mar 16;83(6):824-826.
doi: 10.1016/j.molcel.2023.02.025.

Mitochondria: A "pacemaker" for species-specific development

Yasmine J Liu  1 , Johan Auwerx  2
Affiliations
Free article
Comment

Mitochondria: A "pacemaker" for species-specific development

Yasmine J Liu et al. Mol Cell. .
Free article

Abstract

We highlight papers by Diaz-Cuadros et al.1 and Iwata et al.2 that demonstrate the role of mitochondrial metabolism in setting developmental pace through their control over cellular bioenergetics and redox homeostasis in mice and humans.

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Conflict of interest statement

Declaration of interests J.A. is member of the scientific advisory boards of Mitobridge, MetroBiotech, Amazentis, Vandria, OrsoBio, and NovMetaPharma.

Comment on

  • Metabolic regulation of species-specific developmental rates.
    Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Díaz-García CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquié O. Diaz-Cuadros M, et al. Nature. 2023 Jan;613(7944):550-557. doi: 10.1038/s41586-022-05574-4. Epub 2023 Jan 4. Nature. 2023. PMID: 36599986 Free PMC article.
  • Mitochondria metabolism sets the species-specific tempo of neuronal development.
    Iwata R, Casimir P, Erkol E, Boubakar L, Planque M, Gallego López IM, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Vlaeminck I, Creemers E, Wierda K, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquière B, Fendt SM, Vanderhaeghen P. Iwata R, et al. Science. 2023 Feb 10;379(6632):eabn4705. doi: 10.1126/science.abn4705. Epub 2023 Feb 10. Science. 2023. PMID: 36705539

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