doi: 10.1016/j.ccell.2023.02.013.
Epub 2023 Mar 16.
Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade
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- PMID: 36931275
- DOI: 10.1016/j.ccell.2023.02.013
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Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade
Cancer Cell.
.
Free article
Abstract
Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with enhanced anti-tumor immunity in vivo and improved responsiveness to immune checkpoint blockade therapy in patients with cancer.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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