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. 2023 Jun:167:105473.
doi: 10.1016/j.fitote.2023.105473. Epub 2023 Mar 15.

Structurally diverse glycosides with α-glucosidase inhibitory properties from water extract of the leaves of Cyclocarya paliurus

Li-Ping Zhu  1 , Si-Yang Fang  2 , Xing-Chen Lu  2 , Qing-Qing Wang  3 , Jie Wang  4 , Chang-Qian Fang  5 , Xiao-Gai Zhang  5 , Jian Zhang  6 , Ke Pan  7 , Zhi-Qi Yin  8
Affiliations

Structurally diverse glycosides with α-glucosidase inhibitory properties from water extract of the leaves of Cyclocarya paliurus

Li-Ping Zhu et al. Fitoterapia. 2023 Jun.

Abstract

In this work we investigated the chemical constituents of water extract of the leaves of Cyclocarya paliurus. Two new megastigmane glycosides (3 and 8), three aliphatic alcohol glycosides (9-11), and two aromatic glycosides (12 and 13), along with fourteen known compounds were isolated, and their in vitro inhibitory activity against α-glucosidase was evaluated. Compounds 13 and 15-18 displayed inhibitory activity with IC50 values varying from 27.05 to 96.58 μM, and the structure-activity relationship among isolated compounds was discussed.

Keywords: Cyclocarya paliurus; Hypoglycemic; Large polar components; Water extract; α-glucosidase inhibitors.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

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