Minimally invasive approaches for the early detection of endometrial cancer

doi:10.1186/s12943-023-01757-3

Review

. 2023 Mar 17;22(1):53.

doi: 10.1186/s12943-023-01757-3.

Minimally invasive approaches for the early detection of endometrial cancer

Yufei Shen¹, Wenqing Yang^{1

2}, Jiachen Liu³, Yu Zhang^{4

5}

Affiliations

¹ Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Gynaecology Oncology Research and Engineering Central of Hunan Province, Changsha, Hunan, China.
³ The Center of Systems Biology and Data Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China. ljch1999@csu.edu.cn.
⁴ Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China. xyzhangyu@csu.edu.cn.
⁵ Gynaecology Oncology Research and Engineering Central of Hunan Province, Changsha, Hunan, China. xyzhangyu@csu.edu.cn.

PMID: 36932368
PMCID: PMC10022290
DOI: 10.1186/s12943-023-01757-3

Review

Minimally invasive approaches for the early detection of endometrial cancer

Yufei Shen et al. Mol Cancer. 2023.

. 2023 Mar 17;22(1):53.

doi: 10.1186/s12943-023-01757-3.

Authors

Yufei Shen¹, Wenqing Yang^{1

2}, Jiachen Liu³, Yu Zhang^{4

5}

Affiliations

¹ Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Gynaecology Oncology Research and Engineering Central of Hunan Province, Changsha, Hunan, China.
³ The Center of Systems Biology and Data Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China. ljch1999@csu.edu.cn.
⁴ Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China. xyzhangyu@csu.edu.cn.
⁵ Gynaecology Oncology Research and Engineering Central of Hunan Province, Changsha, Hunan, China. xyzhangyu@csu.edu.cn.

PMID: 36932368
PMCID: PMC10022290
DOI: 10.1186/s12943-023-01757-3

Erratum in

Correction: minimally invasive approaches for the early detection of endometrial cancer.
Shen Y, Yang W, Liu J, Zhang Y. Shen Y, et al. Mol Cancer. 2023 Apr 26;22(1):76. doi: 10.1186/s12943-023-01777-z. Mol Cancer. 2023. PMID: 37101282 Free PMC article. No abstract available.

Abstract

Endometrial cancer (EC) is one of the most common gynecologic cancers and its incidence is rising globally. Although advanced EC has a poor prognosis; diagnosing EC at an earlier stage could improve long-term patient outcomes. However, there is no consensus on the early detection strategies for EC and the current diagnostic practices such as transvaginal ultrasound, hysteroscopy and endometrial biopsy are invasive, costly and low in specificity. Thus, accurate and less invasive screening tests that detect EC in women with early stages of the disease are needed. Current research has revolutionized novel EC early detection methodologies in many aspects. This review aims to comprehensively characterizes minimally invasive screening techniques that can be applied to EC in the future, and fully demonstrate their potential in the early detection of EC.

Keywords: Biofluid; Biomarkers; Early diagnosis; Endometrial cancer; Minimally invasive.

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Conflict of interest statement

Not applicable.

Figures

**Fig. 1**
Minimally invasive approaches in the diagnostic schedule of EC

See this image and copyright information in PMC

Cited by

Correction: minimally invasive approaches for the early detection of endometrial cancer.
Shen Y, Yang W, Liu J, Zhang Y. Shen Y, et al. Mol Cancer. 2023 Apr 26;22(1):76. doi: 10.1186/s12943-023-01777-z. Mol Cancer. 2023. PMID: 37101282 Free PMC article. No abstract available.
Cervicovaginal lavages uncover growth factors as key biomarkers for early diagnosis and prognosis of endometrial cancer.
Harris HJ, Łaniewski P, Cui H, Roe DJ, Chase DM, Herbst-Kralovetz MM. Harris HJ, et al. Mol Biomed. 2024 Nov 8;5(1):55. doi: 10.1186/s43556-024-00219-6. Mol Biomed. 2024. PMID: 39511039 Free PMC article.
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Zheng Z, Liu Y, Feng L, Liu P, Song H, Wang L, Huang F. Zheng Z, et al. Sensors (Basel). 2025 May 6;25(9):2932. doi: 10.3390/s25092932. Sensors (Basel). 2025. PMID: 40363369 Free PMC article.
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Wang T, Yu D, Wang J, Zhu N, Tang XB, Chen X, Su XM, Huang YG. Wang T, et al. Front Oncol. 2023 Nov 2;13:1250558. doi: 10.3389/fonc.2023.1250558. eCollection 2023. Front Oncol. 2023. PMID: 38023184 Free PMC article.
A Predictive Model for Endometrial Carcinoma Based on Hysteroscopic Data.
Wu H, Chen Q, Liu Y, Tang Y, Zhao Y, Zhang X, Chen X, Ying X, Xu B. Wu H, et al. Int J Womens Health. 2023 Oct 30;15:1651-1659. doi: 10.2147/IJWH.S416864. eCollection 2023. Int J Womens Health. 2023. PMID: 37928773 Free PMC article. Clinical Trial.

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References

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[1] Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. - PubMed

[2] Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. - PubMed

[3] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: Cancer J. Clin. 2021;71:209–249. - PubMed

[4] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: Cancer J. Clin. 2021;71:209–249. - PubMed

[5] Gaber C, Meza R, Ruterbusch JJ, Cote ML. Endometrial cancer trends by race and histology in the USA: Projecting the number of new cases from 2015 to 2040. J Racial Ethn Health Disparities. 2016. 10.1007/s40615-016-0292-2. - PMC - PubMed

[6] Gaber C, Meza R, Ruterbusch JJ, Cote ML. Endometrial cancer trends by race and histology in the USA: Projecting the number of new cases from 2015 to 2040. J Racial Ethn Health Disparities. 2016. 10.1007/s40615-016-0292-2. - PMC - PubMed

[7] Sheikh MA, Althouse AD, Freese KE, Soisson S, Edwards RP, Welburn S, Sukumvanich P, Comerci J, Kelley J, LaPorte RE, Linkov F. USA endometrial cancer projections to 2030: should we be concerned? Future Oncology (London, England) 2014;10:2561–2568. doi: 10.2217/fon.14.192. - DOI - PubMed

[8] Sheikh MA, Althouse AD, Freese KE, Soisson S, Edwards RP, Welburn S, Sukumvanich P, Comerci J, Kelley J, LaPorte RE, Linkov F. USA endometrial cancer projections to 2030: should we be concerned? Future Oncology (London, England) 2014;10:2561–2568. doi: 10.2217/fon.14.192. - DOI - PubMed

[9] Makker V, MacKay H, Ray-Coquard I, Levine DA, Westin SN, Aoki D, Oaknin A. Endometrial cancer Nature Reviews Disease Primers. 2021;7:88. doi: 10.1038/s41572-021-00324-8. - DOI - PMC - PubMed

[10] Makker V, MacKay H, Ray-Coquard I, Levine DA, Westin SN, Aoki D, Oaknin A. Endometrial cancer Nature Reviews Disease Primers. 2021;7:88. doi: 10.1038/s41572-021-00324-8. - DOI - PMC - PubMed

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Minimally invasive approaches for the early detection of endometrial cancer

Affiliations

Minimally invasive approaches for the early detection of endometrial cancer

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