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Multicenter Study
. 2023 Mar 18;23(1):121.
doi: 10.1186/s12887-023-03939-w.

Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy

Sevgen Tanır Basaranoğlu  1 , Ayşe Karaaslan  2 , Enes Salı  3 , Ergin Çiftçi  4 , Zeynep Gökçe Gayretli Aydın  5 , Bilge Aldemir Kocabaş  6 , Cemil Kaya  7 , Semra Şen Bayturan  8 , Soner Sertan Kara  9 , Dilek Yılmaz Çiftdoğan  10 , Ümmühan Çay  11 , Hacer Gundogdu Aktürk  12 , Melda Çelik  13 , Halil Ozdemir  4 , Ayper Somer  14 , Tijen Diri  15 , Ahmet Sami Yazar  16 , Murat Sütçü  17 , Hasan Tezer  18 , Eda Karadag Oncel  10 , Manolya Kara  14 , Solmaz Çelebi  19 , Aslınur Özkaya Parlakay  20 , Sabahat Karakaşlılar  21 , Emin Sami Arısoy  22 , Gönül Tanır  23 , Tuğçe Tural Kara  24 , İlker Devrim  25 , Tuğba Erat  4 , Kübra Aykaç  1 , Özge Kaba  14 , Şirin Güven  16 , Edanur Yeşil  19 , Ayşe Tekin Yılmaz  22 , Sevgi Yaşar Durmuş  23 , İlknur Çağlar  25 , Fatih Günay  26 , Metehan Özen  27 , Ener Çağrı Dinleyici  28 , Ateş Kara  29
Affiliations
Multicenter Study

Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy

Sevgen Tanır Basaranoğlu et al. BMC Pediatr. .

Abstract

Background: Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region.

Methods: The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre.

Results: A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect.

Conclusion: This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.

Keywords: Amoxicillin-clavulanate; Antibiotic-associated diarrhea; Cephalosporins; Macrolides; Outpatient clinics; Phenoxymethyl penicillins.

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Conflict of interest statement

We have no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow chart of the study, the inclusion, and the exclusion criteria
Fig. 2
Fig. 2
Population characteristics of pediatric cases. A Distribution of cases according to geographical regions (percent of cases from each region/percent of AAD cases in each region), B Types of infections, and C Types of prescribed antibiotics
Fig. 3
Fig. 3
Follow-up of occurence of AAD according to timing of each antimicrobial treatment. The numbers over the bars show the numbers of case who presented AAD
See this image and copyright information in PMC

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