Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 17;24(1):199.
doi: 10.1186/s13063-023-07207-1.

Effects of repetitive functional magnetic stimulation in the sacral nerve in patients with neurogenic detrusor overactivity after suprasacral spinal cord injury: a study protocol for a randomized controlled trial

Jiyang Li  1 , Jianxiong Wang  1 , Yue Hu  1 , Rui Jian  1 , Yulu Zhao  1 , Dan Li  1 , Tenggang Wan  1 , Wuga Jike  1 , Fangyuan Xu  2 , Maomao Huang  3
Affiliations

Effects of repetitive functional magnetic stimulation in the sacral nerve in patients with neurogenic detrusor overactivity after suprasacral spinal cord injury: a study protocol for a randomized controlled trial

Jiyang Li et al. Trials. .

Abstract

Background: Neurogenic detrusor overactivity (NDO) is a serious and common complication after spinal cord injury, affecting patients' quality of life seriously. Therefore, we developed this research protocol to evaluate the efficacy of repetitive functional magnetic stimulation (rFMS) in the sacral nerve in patients with neurogenic detrusor overactivity (NDO) after suprasacral spinal cord injury (SCI) and provide more options for rFMS in treating NDO after suprasacral SCI.

Methods: This study is a single-center, randomized, parallel-group clinical trial. We will recruit the patients with NDO after suprasacral SCI in the Rehabilitation Department of the Affiliated Hospital of Southwest Medical University from September 2022 to August 2023. They will be assigned to the rFMS group and the sham stimulation group randomly. The sample size is 66, with 33 patients in each group. The rFMS group will receive real rFMS treatment of the sacral nerve (100% stimulation intensity, 5 Hz, 20 min each time, five times a week), and the sham group will receive sham stimulation. Both groups will receive similar treatment strategies, including medication, standard urine management, acupuncture treatment, and health education. The bladder compliance (bladder capacity/detrusor pressure) and pudendal nerve electromyography will be evaluated at baseline, 8th week of treatment. The residual volume of the bladder and bladder diary will be recorded once a week during 8 weeks of treatments. SCI-QOL and NBSS will be evaluated at baseline, the 4th and 8th week of treatment. In addition, the above assessments will be followed up at 8 weeks after the end of treatment.

Discussion: It is expected that the bladder function, symptoms, and quality of life might be significantly improved after rFMS of the sacral nerve.

Trial registration: The China Clinical Trials Registry has approved this study, registration number: ChiCTR2100045148. Registered on April 7, 2021.

Keywords: Bladder function; Neurogenic detrusor overactivity; Physiotherapy; Randomized controlled trial; Repetitive functional magnetic stimulation; Spinal cord injury.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Summary of study protocol
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. terminologyICSCoSo Standardization of terminology of lower urinary tract function. Fourth report: neuromuscular dysfunction. International Continence Society Committee on Standardization of Terminology. Urology. 1981;17(6):618–620. doi: 10.1016/0090-4295(81)90092-3. - DOI - PubMed
    1. Hu HZ, Granger N, Jeffery ND. Pathophysiology, clinical importance, and management of neurogenic lower urinary tract dysfunction caused by suprasacral spinal cord injury. J Vet Intern Med. 2016;30(5):1575–1588. doi: 10.1111/jvim.14557. - DOI - PMC - PubMed
    1. Bayat M, Kumar V, Denis M, Webb J, Gregory A, Mehrmohammadi M, et al. Correlation of ultrasound bladder vibrometry assessment of bladder compliance with urodynamic study results. PLoS ONE. 2017;12(6):e0179598. doi: 10.1371/journal.pone.0179598. - DOI - PMC - PubMed
    1. Kavanagh A, Baverstock R, Campeau L, Carlson K, Cox A, Hickling D, et al. Canadian Urological Association guideline: diagnosis, management, and surveillance of neurogenic lower urinary tract dysfunction - executive summary. Cuaj-Can Urol Assoc. 2019;13(6):156–165. - PMC - PubMed
    1. Bycroft JA, Craggs MD, Sheriff M, Knight S, Shah PJ. Does magnetic stimulation of sacral nerve roots cause contraction or suppression of the bladder? Neurourol Urodyn. 2004;23(3):241–245. doi: 10.1002/nau.20009. - DOI - PubMed

Publication types

MeSH terms