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Case Reports
. 2023 Mar 16;10(3):e01003.
doi: 10.14309/crj.0000000000001003. eCollection 2023 Mar.

Levetiracetam Liver Injury: A Benign Antiepileptic Agent?

Yassmin Hegazy  1   2 , Page Axley  1   3 , Goo Lee  1   4 , Meagan Gray  1   3
Affiliations
Case Reports

Levetiracetam Liver Injury: A Benign Antiepileptic Agent?

Yassmin Hegazy et al. ACG Case Rep J. .

Abstract

Levetiracetam is a commonly prescribed antiepileptic agent and has rarely been linked to hepatotoxicity. This case describes a patient with drug-induced autoimmune hepatitis secondary to levetiracetam.

Keywords: autoimmune hepatitis; levetiracetam; liver injury.

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Figures

Figure 1.
Figure 1.
Liver biopsy findings. (A) A portal tract (arrows) showed mild inflammatory infiltrate consisting predominantly of lymphocytes with mild interface activity, bile duct injury, and bile ductular proliferation. (B) A focus of the centrilobular area demonstrated an inflammatory infiltrate with a cluster of ceroid-laden macrophages and few plasma cells (arrows).
Figure 2.
Figure 2.
The patient's liver injury time line to levetiracetam. ALT, alanine aminotransferase; AST, aspartate aminotransferase; LEV, levetiracetam.
See this image and copyright information in PMC

References

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