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Review
. 2023 Jan 5;2(1):e000218.
doi: 10.1136/bmjmed-2022-000218. eCollection 2023.

Role of precision medicine in obstructive sleep apnoea

Yu Liu  1   2 , Ali Abdul Ghafoor  2 , Mohammadreza Hajipour  3 , Najib Ayas  2   4   5
Affiliations
Review

Role of precision medicine in obstructive sleep apnoea

Yu Liu et al. BMJ Med. .

Abstract

Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patients have varied susceptibility to long term complications and different responses to treatment. This narrative review summarises the current knowledge of precision medicine in obstructive sleep apnoea, particularly the role of symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers in defining subtypes. In the near future, the prognostic accuracy of these measures in predicting long term complications in obstructive sleep apnoea will likely be improved, together with better matching of treatments to disease subtypes.

Keywords: Medicine; Public health; Sleep medicine specialty; Therapeutics.

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Conflict of interest statement

Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following interests: none.

Figures

Figure 1
Figure 1
Precision care management for obstructive sleep apnoea with symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers. PSG=polysomnography; EEG=electroencephalography; ECG=electrocardiography; EMG=electromyography
See this image and copyright information in PMC

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