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. 2023 Mar 3:13:1033154.
doi: 10.3389/fonc.2023.1033154. eCollection 2023.

Survival rate of colorectal cancer in China: A systematic review and meta-analysis

Ren Wang  1 , Jie Lian  1 , Xin Wang  1 , Xiangyi Pang  1 , Benjie Xu  1 , Shuli Tang  1 , Jiayue Shao  1 , Haibo Lu  1
Affiliations

Survival rate of colorectal cancer in China: A systematic review and meta-analysis

Ren Wang et al. Front Oncol. .

Abstract

Background: This study aims to comprehensively summarize the colorectal survival rate in China. Method: In PubMed and Web of Science, keywords such as "colorectal cancer", "survival" and "China" were used to search literatures in the past 10 years. Random effect models were selected to summarize 1-year, 3-year, and 5-year survival rates, and meta-regression and subgroup analyses were performed on the included studies.

Results: A total of 16 retrospective and prospective studies providing survival rates for colorectal cancer in China were included. The 1-year, 3-year, and 5-year survival rates of colorectal cancer in China were 0.79, 0.72 and 0.62, respectively. In the included studies, the 5-year survival rates of stage I (5474 cases), stage II (9215 cases), stage III (8048 cases), and stage IV (4199 cases) colorectal cancer patients were 0.85, 0.81, 0.57 and 0.30, respectively. Among them, the 5-year survival rates of colorectal cancer were 0.82, 0.76, 0.71, 0.67, 0.66, 0.65 and 0.63 in Tianjin, Beijing, Guangdong, Shandong, Liaoning, Zhejiang and Shanghai, respectively.

Conclusion: The 5-year survival rate in China is close to that of most European countries, but still lower than Japan and South Korea, and the gap is gradually narrowing. Region, stage, differentiation, pathological type, and surgical approach can affect 5-year survival in colorectal cancer.

Systematic review registration: https://www.crd.york.ac.uk/prospero/ identifier, CRD42022357789.

Keywords: China; colorectal cancer; epidemiology; meta-analysis; overall survival.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of Search and Studies Selection.
Figure 2
Figure 2
Pooled survival rate. (A) Forest plot of pooled 1-year survival rate in patients with colorectal cancer. (B) Forest plot of pooled 3-year survival rate in patients with colorectal cancer. (C) Forest plot of pooled 5-year survival rate in patients with colorectal cancer. (D) Histogram of pooled 1, 3, 5-year survival rate in patients with colorectal cancer.
Figure 3
Figure 3
Survival rates in different regions (A) Forest plot of survival rates in different regions. (B) Histogram of survival rates in different regions.
Figure 4
Figure 4
Subgroup analysis. (A) Forest plot of subgroup analysis based on stage. (B) Forest plot of subgroup analysis based on differentiation. (C) Forest plot of subgroup analysis based on pathological type. (D) Forest plot of subgroup analysis based on surgical method. (E) Histogram of subgroup analysis based on stage, differentiation, pathological type and surgical method. AC, Adenocarcinoma; MAC, Mucinous adenocarcinoma.
Figure 5
Figure 5
Egger’s publication bias plot and sensitivity analysis. (A) Egger’s publication bias plot based on 5-year survival rate. (B) Sensitivity analysis based on 5-year survival rate. Every horizontal line representing combined 5-year survival and the range of 95% CI after omitting study of the included studies one by one.
See this image and copyright information in PMC

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