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. 2023 Jan 13;21(2):41-46.
doi: 10.1097/CLD.0000000000000005. eCollection 2023 Feb.

From cause to consequence: Insights into incident diabetes mellitus after hepatic steatosis

Manik Aggarwal  1 , Christina C Lindenmeyer  2
Affiliations

From cause to consequence: Insights into incident diabetes mellitus after hepatic steatosis

Manik Aggarwal et al. Clin Liver Dis (Hoboken). .
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Proposed pathogenesis of diabetes mellitus in NAFLD. Free fatty acids (FFA) from adipose tissue and/or dietary sources are converted to ceramides and diacylglycerols (DAG). Ceramides and DAG impair hepatic insulin signaling, activate protein kinase C (PKC) and increase oxidative stress. This results in hepatic insulin resistance (IR) and a systemic inflammatory state eventually leading to hyperglycemia. Further coupled with intestinal dysbiosis, altered bile acid profile and decreased insulin clearance from hepatic fat deposition eventually lead to beta-cell dysfunction and incident diabetes mellitus.TG, triglyceride.
FIGURE 2
FIGURE 2
Bidirectional relationship between NAFLD and type II diabetes mellitus (DM). DM drives NAFLD progression whereas NAFLD exacerbates microvascular and macrovascular DM complications.
See this image and copyright information in PMC

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