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. 2023 Sep;43(5):1374-1410.
doi: 10.1002/med.21953. Epub 2023 Mar 20.

A comprehensive and systemic review of ginseng-based nanomaterials: Synthesis, targeted delivery, and biomedical applications

Sri Renukadevi Balusamy  1 , Haribalan Perumalsamy  2   3   4 , Md Amdadul Huq  5 , Tae Hyun Yoon  2   3   4 , Ivan Mijakovic  6   7 , Lakshmi Thangavelu  8 , Deok Chun Yang  9   10 , Shadi Rahimi  6
Affiliations

A comprehensive and systemic review of ginseng-based nanomaterials: Synthesis, targeted delivery, and biomedical applications

Sri Renukadevi Balusamy et al. Med Res Rev. 2023 Sep.

Abstract

Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano-ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.

Keywords: Panax species; biomedical applications; ginseng nanoparticle synthesis; ginsenoside based nanoparticles; green synthesis; microbial synthesis; polymer-based ginsenoside nanocarrier; targeted delivery.

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References

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