Molecular principles of tissue invasion and metastasis

Abstract

Cancer-associated metastasis is the primary cause of morbidity and mortality. Yet, its underlying biological mechanism remains poorly understood. Efforts to prevent or delay metastasis require a deep understanding of the underlying molecular mechanisms. However, continued advancement in cancer biology research has improved the comprehensive understanding of some of the molecular keystones of the dissemination process. However, the emergence of new paradigms in the study of metastasis intuitively recognizes the involvement of genetics, epigenetics, extrinsic traits, and tumor microenvironment in metastatic initiation, progression, and colonization. On their way to the target site, the disseminated tumor cells interact with multiplex of proteins and cells. Identification of mechanisms underlying metastatic program is crucial for developing effective and efficient therapeutic interventions. In this review, we discuss details about recent advancements in the field of metastasis and organotropism, also highlights the role of genetics, epigenetics, exosomes, circadian rhythm, microbiome, integrins, and other adhesion molecules, and chemokines in the regulation of metastatic events.

Keywords: circulating tumor cells; dormancy; epithelial-mesenchymal transition; metabolic profile of cancer cell; metastasis.