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Randomized Controlled Trial
. 2023 Mar-Apr;34(2):127-134.
doi: 10.1089/derm.2022.29002.flf.

Effectiveness of a Skin Care Program With a Cream Containing Ceramide C and a Personalized Training for Secondary Prevention of Hand Contact Dermatitis

Francesca Larese Filon  1 , Pietro Maculan  2 , Maria Angiola Crivellaro  2 , Marcella Mauro  1
Affiliations
Randomized Controlled Trial

Effectiveness of a Skin Care Program With a Cream Containing Ceramide C and a Personalized Training for Secondary Prevention of Hand Contact Dermatitis

Francesca Larese Filon et al. Dermatitis. 2023 Mar-Apr.

Abstract

Background/Objectives: The aim of our study was to investigate the effectiveness of personalized training on skin protection associated with the regular use of ceramide-containing cream (CC) versus other creams (OC) for improving hand contact dermatitis. Methods: We performed a double-center randomized trial that enrolled workers with hand dermatitis. All workers received personalized training. The intervention was 3 times per day application of the study emollient. The control arm used an emollient of choice without ceramide, as needed. The primary outcome was improvement in hand dermatitis at 1 and 3 months of follow-up. Results: In total, 102 patients with hand dermatitis were enrolled in this study. Improvement in dermatitis was found in 40%, 52.5%, 50%, and 63% of OC and CC, at the first and second follow-ups, respectively. The use of CC was significantly associated with an improvement in dermatitis (odds ratios 2.6; 95% confidence intervals 1.30-5.2), analyzed using generalized equation estimation during the follow-up. Conclusion: Our study demonstrated that an educational personalized intervention could improve the signs and symptoms in patients with hand dermatitis, and the use of a CC resulted in a significantly better outcome during the 3 months of follow-up.

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Figures

Figure 1.
Figure 1.
Lay-out of the study.
Figure 2.
Figure 2.
HECSI score trend from T0 to T1 in subjects treated with CC and OCs. HECSI, hand eczema severity index; CC, ceramide cream; OCs, other creams.
Figure 3.
Figure 3.
TEWL measurement at hand and forearm at T0 and T2 in subjects treated with CC and OCs. CC, ceramide cream; OCs, other creams; TEWL, trans epidermal water loss.
Figure 4.
Figure 4.
HECSI score, TEWL at hand and forearm trends (better, same, or worse) at T0 and T1 in subjects treated with CC and OCs. CC, ceramide cream; HECSI, hand eczema severity index; OCs, other creams; TEWL, trans epidermal water loss.
See this image and copyright information in PMC

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