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Review
. 2023 Oct;32(5):e13831.
doi: 10.1111/jsr.13831. Epub 2023 Mar 20.

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Yusing Gu  1 , Jean-François Gagnon  2   3 , Marta Kaminska  4   5
Affiliations
Review

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Yusing Gu et al. J Sleep Res. 2023 Oct.

Abstract

Obstructive sleep apnea has been associated with cognitive impairment and may be linked to disorders of cognitive function. These associations may be a result of intermittent hypoxaemia, sleep fragmentation and changes in sleep microstructure in obstructive sleep apnea. Current clinical metrics of obstructive sleep apnea, such as the apnea-hypopnea index, are poor predictors of cognitive outcomes in obstructive sleep apnea. Sleep microstructure features, which can be identified on sleep electroencephalography of traditional overnight polysomnography, are increasingly being characterized in obstructive sleep apnea and may better predict cognitive outcomes. Here, we summarize the literature on several major sleep electroencephalography features (slow-wave activity, sleep spindles, K-complexes, cyclic alternating patterns, rapid eye movement sleep quantitative electroencephalography, odds ratio product) identified in obstructive sleep apnea. We will review the associations between these sleep electroencephalography features and cognition in obstructive sleep apnea, and examine how treatment of obstructive sleep apnea affects these associations. Lastly, evolving technologies in sleep electroencephalography analyses will also be discussed (e.g. high-density electroencephalography, machine learning) as potential predictors of cognitive function in obstructive sleep apnea.

Keywords: K-complex; cyclic alternating pattern; odds ratio product; quantitative electroencephalography; sleep spindles; slow-wave activity.

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References

REFERENCES

    1. Afifi, L., Guilleminault, C., & Colrain, I. M. (2003). Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS. Respiratory Physiology & Neurobiology, 136(2-3), 221-234. https://doi.org/10.1016/s1569-9048(03)00084-3
    1. Ancoli-Israel, S., Palmer, B. W., Cooke, J. R., Corey-Bloom, J., Fiorentino, L., Natarajan, L., Liu, L., Ayalon, L., He, F., & Loredo, J. S. (2008). Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. Journal of the American Geriatrics Society, 56(11), 2076-2081. https://doi.org/10.1111/j.1532-5415.2008.01934.x
    1. Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S. (2018). The relationship between Obstructive Sleep Apnea and Alzheimer's Disease. Journal of Alzheimer's Disease, 64(s1), S255-S270. https://doi.org/10.3233/JAD-179936
    1. Appleton, S. L., Vakulin, A., D'Rozario, A., Vincent, A. D., Teare, A., Martin, S. A., Wittert, G. A., McEvoy, R. D., Catcheside, P. G., & Adams, R. J. (2019). Quantitative electroencephalography measures in rapid eye movement and nonrapid eye movement sleep are associated with apnea-hypopnea index and nocturnal hypoxemia in men. Sleep, 42(7), zsz092. https://doi.org/10.1093/sleep/zsz092
    1. Aricò, D., Drago, V., Foster, P. S., Heilman, K. M., Williamson, J., & Ferri, R. (2010). Effects of NREM sleep instability on cognitive processing. Sleep Medicine, 11(8), 791-798. https://doi.org/10.1016/j.sleep.2010.02.009

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