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Case Reports
. 2023 Dec 31;19(1):2187591.
doi: 10.1080/21645515.2023.2187591. Epub 2023 Mar 21.

Successful treatment of anogenital warts with single dose Bacillus Calmette Guerin vaccine without prior sensitization in tuberculosis endemic country: Two case report

Pati Aji Achdiat  1   2 , Oki Suwarsa  1 , Yudi Mulyana Hidayat  3 , Mohamad Nasir Shafiee  4 , Reiva Farah Dwiyana  1 , Hendra Gunawan  1 , Rasmia Rowawi  1 , Reyshiani Johan  1
Affiliations
Case Reports

Successful treatment of anogenital warts with single dose Bacillus Calmette Guerin vaccine without prior sensitization in tuberculosis endemic country: Two case report

Pati Aji Achdiat et al. Hum Vaccin Immunother. .

Abstract

Anogenital Warts (AGWs) are benign proliferations caused by Human Papillomavirus (HPV) infection on the genital or anal areas. Various therapeutic options are available for the treatment of AGWs but there is no best or ideal therapy, and the recurrence of AGWs is significantly high. A promising new therapy that is currently being evaluated is immunotherapy with the intralesional Bacillus Calmette-Guérin (BCG) vaccine. Two cases of a 23-year-old woman and a 41-year-old man were presented with manifestations of condyloma acuminata type AGWs. The patients were immunocompetent and received single dose intralesional BCG vaccine on the largest lesion. Clinical improvements of AGWs lesions were noted starting on the 14th day after receiving therapy by the disappearance of some lesions with no recurrence and side effects. Intralesional BCG vaccine activates the immune system, treats other AGWs lesions that do not receive an intralesional injection, and also prevents recurrence. Although the intralesional BCG vaccine is effective for treating AGWs, further evaluation is still needed for its recurrence.

Keywords: Anogenital warts; Bacillus Calmette-Guérin; immunotherapy.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
(a) Clinical manifestation of anogenital wart on vulva area before intralesional BCG injection; (b) some of the warty lesion demonstrate complete clearing one month after injection.
Figure 2.
Figure 2.
(a) Clinical manifestation of anogenital warts on penis shaft before intralesional BCG injection; (b) some of the warty lesion demonstrate complete clearing within 1 month.
See this image and copyright information in PMC

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