Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 1;63(6):ezad100.
doi: 10.1093/ejcts/ezad100.

Andexanet alfa in acute aortic syndrome: first UK experience

Nawwar Al-Attar  1 , Ahmed F Sedeek  1 , Philip McCall  2 , Jennifer Travers  3
Affiliations

Andexanet alfa in acute aortic syndrome: first UK experience

Nawwar Al-Attar et al. Eur J Cardiothorac Surg. .

Abstract

Andexanet alfa was employed to reverse the anticoagulant effect of direct oral anticoagulants in 3 patients who required emergent surgery for repair of type A aortic dissection. Its use was instrumental in securing haemostasis. However, we caution against the administration of Andexanet alfa prior to cardiopulmonary bypass as it can induce heparin resistance and complicate the perioperative monitoring of anticoagulation during cardiopulmonary bypass.

Keywords: Acute aortic syndrome; Andexanet alfa; Aorta; Bleeding; Emergency.

PubMed Disclaimer

Comment in

LinkOut - more resources