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Review
. 2024 Jan;479(1):1-11.
doi: 10.1007/s11010-023-04707-1. Epub 2023 Mar 21.

Emerging role of lipophagy in liver disorders

Bismillah Nazeer #  1 , Muhammad Babar Khawar #  2 , Muhammad Usman Khalid #  1 , Syeda Eisha Hamid #  1 , Mussarat Rafiq #  3 , Muddasir Hassan Abbasi  4 , Nadeem Sheikh  5 , Ahmad Ali  1 , Hooriya Fatima  1 , Sadia Ahmad  1
Affiliations
Review

Emerging role of lipophagy in liver disorders

Bismillah Nazeer et al. Mol Cell Biochem. 2024 Jan.

Abstract

Lipophagy is a selective degradation of lipids by a lysosomal-mediated pathway, and dysregulation of lipophagy is linked with the pathological hallmark of many liver diseases. Downregulation of lipophagy in liver cells results in abnormal accumulation of LDs (Lipid droplets) in hepatocytes which is a characteristic feature of several liver pathologies such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Contrarily, upregulation of lipophagy in activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and cirrhosis. Lipid metabolism reprogramming in violent cancer cells contributes to the progression of liver cancer. In this review, we have summarized the recent studies focusing on various components of the lipophagic machinery that can be modulated for their potential role as therapeutic agents against a wide range of liver diseases.

Keywords: HSCs; Lipophagy; NAFLD; NASH; Therapeutic agents.

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