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Review
. 2023 Jun 1;35(3):238-245.
doi: 10.1097/GCO.0000000000000870. Epub 2023 Mar 17.

The importance of follicular flushing in optimizing oocyte retrieval

George Lainas  1 , Tryfon Lainas  1 , Efstratios Kolibianakis  2
Affiliations
Review

The importance of follicular flushing in optimizing oocyte retrieval

George Lainas et al. Curr Opin Obstet Gynecol. .

Abstract

Purpose of review: To critically evaluate the use of follicular flushing during oocyte retrieval.

Recent findings: The latest meta-analysis evaluating follicular flushing does not favour its use over single aspiration. The randomized controlled trials (RCTs) included, however, are characterized by significant heterogeneity regarding the population analysed, the needle type and lumen used, the aspiration pressure applied and the number of flushing attempts performed. More importantly, information regarding the flow rate used for aspiration is scarce. The only RCT employing a constant flow rate between single aspiration and follicular flushing in women with monofollicular development, suggests that a higher number of oocytes is retrieved after follicular flushing.

Summary: In order to eliminate clinical heterogeneity that might obscure the detection of the true effect of follicular flushing, randomization to single aspiration and follicular flushing should occur within the same patient. This can be achieved by randomly allocating each patient's ovary to either single aspiration or follicular flushing, maintaining similar flow rates between the groups compared.Given the importance of maximizing the number of oocytes retrieved from a given number of follicles developed, the conduction of properly designed RCTs evaluating follicular flushing is certainly required.

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References

    1. Devesa M, Tur R, Rodríguez I, et al. Cumulative live birth rates and number of oocytes retrieved in women of advanced age. A single centre analysis including 4500 women ≥38 years old. Hum Reprod 2018; 33:2010–2017.
    1. Drakopoulos P, Errázuriz J, Santos-Ribeiro S, et al. Cumulative live birth rates in in-vitro fertilization. Minerva Ginecol 2019; 71:207–210.
    1. Polyzos NP, Drakopoulos P, Parra J, et al. Cumulative live birth rates according to the number of oocytes retrieved after the first ovarian stimulation for in vitro fertilization/intracytoplasmic sperm injection: a multicenter multinational analysis including -15,000 women. Fertil Steril 2018; 110:661–670.e1.
    1. Fanton M, Cho JH, Baker VL, Loewke K. A higher number of oocytes retrieved is associated with an increase in 2PNs, blastocysts, and cumulative live birth rates. Fertil Steril 2023.
    1. Tan SL, Waterstone J, Wren M, Parsons J. A prospective randomized study comparing aspiration only with aspiration and flushing for transvaginal ultrasound-directed oocyte recovery. Fertil Steril 1992; 58:356–360.