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Comment
. 2023 Mar 21;8(1):135.
doi: 10.1038/s41392-023-01390-y.

FXR inhibition: an innovative prophylactic strategy against SARS-CoV-2 infection

Zhe Li  1 , Shuai Wang  1 , Fangfang Zhou  2
Affiliations
Comment

FXR inhibition: an innovative prophylactic strategy against SARS-CoV-2 infection

Zhe Li et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The schematic diagram of FXR signaling controlling ACE2 expression. Left, CDCA binds to and activates FXR, which further induces ACE2 expression. Right, FXR inhibitors, including UDCA and the ZGG, diminish ACE2 expression and thereby reduce the susceptibility to SARS-CoV-2 infection
See this image and copyright information in PMC

Comment on

  • FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
    Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott WE 3rd, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS, Darvish-Damavandi M, Mulcahy VL, Kuc RE, Williams TL, Heslop JA, Rossetti D, Tysoe OC, Galanakis V, Vila-Gonzalez M, Crozier TWM, Bargehr J, Sinha S, Upponi SS, Fear C, Swift L, Saeb-Parsy K, Davies SE, Wester A, Hagström H, Melum E, Clements D, Humphreys P, Herriott J, Kijak E, Cox H, Bramwell C, Valentijn A, Illingworth CJR; UK-PBC Consortium; Dahman B, Bastaich DR, Ferreira RD, Marjot T, Barnes E, Moon AM, Barritt AS 4th, Gupta RK, Baker S, Davenport AP, Corbett G, Gorgoulis VG, Buczacki SJA, Lee JH, Matheson NJ, Trauner M, Fisher AJ, Gibbs P, Butler AJ, Watson CJE, Mells GF, Dougan G, Owen A, Lohse AW, Vallier L, Sampaziotis F. Brevini T, et al. Nature. 2023 Mar;615(7950):134-142. doi: 10.1038/s41586-022-05594-0. Epub 2022 Dec 5. Nature. 2023. PMID: 36470304 Free PMC article.

References

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