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. 2023 May;23(5):267-268.
doi: 10.1038/s41577-023-00868-8.

We need to keep an eye on avian influenza

Affiliations

We need to keep an eye on avian influenza

Florian Krammer et al. Nat Rev Immunol. 2023 May.

Abstract

H5N1 avian influenza viruses of the A/goose/Guangdong/1/96 lineage have been circulating in wild birds for many years, have inflicted significant economic losses on the poultry industry and have caused zoonotic infections since 1997. However, the recent spread of avian H5N1 virus to the Americas and its detection in mammals have raised concerns about its pandemic potential.

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Conflict of interest statement

F.K. has been consulting for Curevac, Seqirus and Merck and is currently consulting for Pfizer, Third Rock Ventures, Avimex and GSK. He is named on several patents regarding influenza virus and SARS-CoV-2 vaccines, influenza virus therapeutics and SARS-CoV-2 serological tests. Some of these technologies have been licensed to commercial entities and F.K. is receiving royalties from these entities. F.K. is also an advisory board member of Castlevax, a spin-off company formed by the Icahn School of Medicine at Mount Sinai to develop SARS-CoV-2 vaccines. The Krammer laboratory has received funding for research projects from Pfizer, GSK and Dynavax and three of F.K.’s mentees have recently joined Moderna. S.S.-C. declares no competing interests.

References

    1. Maurer-Stroh S, Lee RT, Gunalan V, Eisenhaber F. The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA. Virol. J. 2013;10:139. doi: 10.1186/1743-422X-10-139. - DOI - PMC - PubMed
    1. Lee DH, Torchetti MK, Killian ML, Swayne DE. Deep sequencing of H7N8 avian influenza viruses from surveillance zone supports H7N8 high pathogenicity avian influenza was limited to a single outbreak farm in Indiana during 2016. Virology. 2017;507:216–219. doi: 10.1016/j.virol.2017.04.025. - DOI - PubMed
    1. Bertran K, et al. Pathobiology of Tennessee 2017 H7N9 low and high pathogenicity avian influenza viruses in commercial broiler breeders and specific pathogen free layer chickens. Vet. Res. 2018;49:82. doi: 10.1186/s13567-018-0576-0. - DOI - PMC - PubMed
    1. Herfst S, et al. Hemagglutinin traits determine transmission of avian A/H10N7 influenza virus between mammals. Cell Host Microbe. 2020;28:602–613. doi: 10.1016/j.chom.2020.08.011. - DOI - PMC - PubMed
    1. Xu X, Subbarao K, Cox NJ, Guo Y. Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology. 1999;261:15–19. doi: 10.1006/viro.1999.9820. - DOI - PubMed

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