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Clinical Trial
. 2023 Jul;294(1):47-57.
doi: 10.1111/joim.13618. Epub 2023 Mar 22.

Moderate dietary salt restriction improves blood pressure and mental well-being in patients with primary aldosteronism: The salt CONNtrol trial

Holger Schneider  1 , Anna-Lina Sarkis  1 , Lisa Sturm  1 , Vera Britz  1 , Andreas Lechner  2   3   4 , Anne L Potzel  5   3   4 , Lisa Marie Müller  1 , Daniel A Heinrich  1 , Heike Künzel  1 , Hanna F Nowotny  1 , Thomas Marchant Seiter  1 , Sonja Kunz  1 , Martin Bidlingmaier  1 , Martin Reincke  1 , Christian Adolf  1
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Free article
Clinical Trial

Moderate dietary salt restriction improves blood pressure and mental well-being in patients with primary aldosteronism: The salt CONNtrol trial

Holger Schneider et al. J Intern Med. 2023 Jul.
Free article

Abstract

Background: Primary aldosteronism (PA) is a frequent cause of hypertension. Aldosterone excess together with high dietary salt intake aggravates cardiovascular damage, despite guideline-recommended mineralocorticoid receptor antagonist (MRA) treatment.

Objectives: To investigate the antihypertensive impact of a moderate dietary salt restriction and associated physiological changes, including mental well-being.

Methods: A total of 41 patients with PA on a stable antihypertensive regimen-including MRA-followed a dietary salt restriction for 12 weeks with structured nutritional training and consolidation by a mobile health app. Salt intake and adherence were monitored every 4 weeks using 24-h urinary sodium excretion and nutrition protocols. Body composition was assessed by bioimpedance analysis and mental well-being by validated questionnaires.

Results: Dietary salt intake significantly decreased from 9.1 to 5.2 g/d at the end of the study. In parallel, systolic (130 vs. 121 mm Hg) and diastolic blood pressure (BP) (84 vs. 81 mm Hg) improved significantly. Patients' aptitude of estimating dietary salt content was refined significantly (underestimation by 2.4 vs. 1.4 g/d). Salt restriction entailed a significant weight loss of 1.4 kg, improvement in pulse pressure (46 vs. 40 mm Hg) and normalization of depressive symptoms (PHQD scale, p < 0.05). Salt restriction, cortisol after dexamethasone suppression test and dosage of renin-angiotensin-aldosterone-system (RAAS) blockers were independently associated with BP reduction.

Conclusion: A moderate restriction of dietary salt intake in patients with PA substantially reduces BP and depressive symptoms. Moreover, the findings underline that a sufficient RAAS blockade seems to augment the effects of salt restriction on BP and cardiovascular risk.

Keywords: aldosterone; cardiovascular risk; hypertension; mineralocorticoid receptor antagonist; salt restriction; salt sensitivity; sodium.

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