Targeting MCAM for next-generation modulation of leucocyte trafficking
- PMID: 36946303
- PMCID: PMC10115349
- DOI: 10.1093/brain/awad079
Targeting MCAM for next-generation modulation of leucocyte trafficking
Abstract
This scientific commentary refers to ‘MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes’ by Charabati et al. (
Conflict of interest statement
The authors report no competing interests.
Comment on
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MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes.Brain. 2023 Apr 19;146(4):1483-1495. doi: 10.1093/brain/awac389. Brain. 2023. PMID: 36319587 Free PMC article.
References
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- Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. J Immunol. 2007;179:6673–6685. - PubMed
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