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. 2023 Apr;95(4):e28691.
doi: 10.1002/jmv.28691.

SARS-CoV-2 infection alters the gut microbiome in diabetes patients: A cross-sectional study from Bangladesh

Adnan Mannan  1   2 , M Nazmul Hoque  3 , Sajjad Hossain Noyon  1   2 , H M Hamidullah Mehedi  4 , Md Javed Foysal  5 , Asma Salauddin  1   2 , S M Rafiqul Islam  1   2 , Farjana Sharmen  1   2 , Afroza Akter Tanni  1   2 , Amam Zonaed Siddiki  6 , Alfred Tay  7 , Md Moradul Siddique  8 , M Shaminur Rahman  9 , Syed Md Galib  8 , Farhana Akter  10
Affiliations

SARS-CoV-2 infection alters the gut microbiome in diabetes patients: A cross-sectional study from Bangladesh

Adnan Mannan et al. J Med Virol. 2023 Apr.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] J Med Virol. 2023 May;95(5):e28828. doi: 10.1002/jmv.28828. J Med Virol. 2023. PMID: 37226969 No abstract available.

Abstract

Populations of different South Asian nations including Bangladesh reportedly have a high risk of developing diabetes in recent years. This study aimed to investigate the differences in the gut microbiome of COVID-19-positive participants with or without type 2 diabetes mellitus (T2DM) compared with healthy control subjects. Microbiome data of 30 participants with T2DM were compared with 22 age-, sex-, and body mass index (BMI)-matched individuals. Clinical features were recorded while fecal samples were collected aseptically from the participants. Amplicon-based (16S rRNA) metagenome analyses were employed to explore the dysbiosis of gut microbiota and its correlation with genomic and functional features in COVID-19 patients with or without T2DM. Comparing the detected bacterial genera across the sample groups, 98 unique genera were identified, of which 9 genera had unique association with COVID-19 T2DM patients. Among different bacterial groups, Shigella (25%), Bacteroides (23.45%), and Megamonas (15.90%) had higher mean relative abundances in COVID-19 patients with T2DM. An elevated gut microbiota dysbiosis in T2DM patients with COVID-19 was observed while some metabolic functional changes correlated with bidirectional microbiome dysbiosis between diabetes and non-diabetes humans gut were also found. These results further highlight the possible association of COVID-19 infection that might be linked with alteration of gut microbiome among T2DM patients.

Keywords: Bangladesh; COVID-19; diabetes; gut microbiome; metagenome.

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References

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