Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

Tiuri E Kroese¹, Hanneke W M van Laarhoven², Sebastian F Schoppman³, Pieter R A J Deseyne⁴, Eric van Cutsem⁵, Karin Haustermans⁶, Philippe Nafteux⁷, Melissa Thomas⁸, Radka Obermannova⁹, Hanna R Mortensen¹⁰, Marianne Nordsmark¹¹, Per Pfeiffer¹², Anneli Elme¹³, Antoine Adenis¹⁴, Guillaume Piessen¹⁵, Christiane J Bruns¹⁶, Florian Lordick¹⁷, Ines Gockel¹⁸, Markus Moehler¹⁹, Cihan Gani²⁰, Theodore Liakakos²¹, John Reynolds²², Alessio G Morganti²³, Riccardo Rosati²⁴, Carlo Castoro²⁵, Francesco Cellini²⁶, Domenico D'Ugo²⁷, Franco Roviello²⁸, Maria Bencivenga²⁹, Giovanni de Manzoni²⁹, Mark I van Berge Henegouwen³⁰, Maarten C C M Hulshof³¹, Jolanda van Dieren³², Marieke Vollebergh³³, Johanna W van Sandick³⁴, Paul Jeene³⁵, Christel T Muijs³⁶, Marije Slingerland³⁷, Francine E M Voncken³⁸, Henk Hartgrink³⁹, Geert-Jan Creemers⁴⁰, Maurice J C van der Sangen⁴¹, Grard Nieuwenhuijzen⁴², Maaike Berbee⁴³, Marcel Verheij⁴⁴, Bas Wijnhoven⁴⁵, Laurens V Beerepoot⁴⁶, Nadia H Mohammad⁴⁷, Stella Mook⁴⁸, Jelle P Ruurda⁴⁹, Piotr Kolodziejczyk⁵⁰, Wojciech P Polkowski⁵¹, Lucjan Wyrwicz⁵², Maria Alsina⁵³, Manuel Pera⁵⁴, Tania F Kanonnikoff⁵⁵, Andrés Cervantes⁵⁵, Magnus Nilsson⁵⁶, Stefan Monig⁵⁷, Anna D Wagner⁵⁸, Matthias Guckenberger⁵⁹, Ewen A Griffiths⁶⁰, Elizabeth Smyth⁶¹, George B Hanna⁶², Sheraz Markar⁶², M Asif Chaudry⁶³, Maria A Hawkins⁶⁴, Edward Cheong⁶⁵, Richard van Hillegersberg⁴⁹, Peter S N van Rossum⁶⁶; OMEC collaborators

Collaborators, Affiliations

Collaborators

OMEC collaborators:
Tom Rozema, Joos Heisterkamp, Markus Schaefer, Esat-Mahmut Ozsahin, Jacco de Haan, Jan Willem van den Berg, Frederic Duprez, Eduard Callebout, Elke van Daele, Ulrich Hacker, Albrecht Hoffmeister, Thomas Kuhnt, Timm Denecke, Regine Kluge, Gerald Prager, A Ilhan-Mutlu, Dajana Cuicchi, Andrea Ardizzoni, Camiel Rosman, Elske C Gootjes, Heidi Rütten, Francesco Puccetti, Stefano Cascinu, Najla Slim, Maria Eugenia Barrios, Maria Carmen Fernandez, Roberto Martí-Oriol, Marisol Huerta Alvaro, Almudena Vera, Esther Jordá, Fernando L Mozos, Anna Reig, Laura Visa, Bogumiła Ciseł, Joanna Czechowska, Magdalena Kwietniewska, Agnieszka Pikuła, Magdalena Skórzewska, Aleksandra Kozłowska, Karol Rawicz-Pruszyński

Affiliations

¹ Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: https://twitter.com/TEKroese.
² Amsterdam UMC Location University of Amsterdam, Department of Medical Oncology, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
³ Department of Surgery, Medical University of Vienna, Vienna University, Vienna, Austria.
⁴ Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
⁵ Department of Medical Oncology, KU Leuven, Leuven University, Leuven, Belgium.
⁶ Department of Radiation Oncology, KU Leuven, Leuven University, Leuven, Belgium.
⁷ Department of Surgery, KU Leuven, Leuven University, Leuven, Belgium.
⁸ Department of Radiation Oncology, AZ Sint Maarten, Mechelen, Belgium.
⁹ Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk, University Brno, Brno, Czech Republic.
¹⁰ Danish Center of Particle Therapy, Aarhus University Medical Center, Aarhus University, Aarhus, Denmark.
¹¹ Department of Radiation Oncology, Aarhus University Medical Center, Aarhus University, Aarhus, Denmark.
¹² Department of Medical Oncology, Odense University Medical Center, University of Odense, Odense, Denmark.
¹³ Department of Medical Oncology, Tallinn University Hospital, Tallinn University, Tallinn, Estonia.
¹⁴ Department of Medical Oncology, IRCM, Inserm, Université Montpellier, ICM, Montpellier, France.
¹⁵ Department of Surgery, Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
¹⁶ Department of Surgery, University Hospital Cologne, University of Cologne, Cologne, Germany.
¹⁷ Department of Medical Oncology, University Hospital Leipzig, University of Leipzig, Leipzig Germany.
¹⁸ Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, University of Leipzig, Leipzig Germany.
¹⁹ Department of Medicine, Johannes Gutenberg-University Clinic, University of Mainz, Mainz, Germany.
²⁰ Department of Radiation Oncology, University Hospital Tubingen, University of Tubingen, Tubingen, Germany.
²¹ Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
²² Department of Surgery, St. James Hospital, Trinity College Dublin, Dublin, Ireland.
²³ Department of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Radiation Oncology, DIMES, Alma Mater Studiorum - Bologna University, Bologna, Italy.
²⁴ Department of GI Surgery, San Raffaele Hospital, San Raffaele Vita-salute University, Milan, Italy.
²⁵ Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; Upper GI and General Surgery Division, Department of Surgery IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
²⁶ Università Cattolica Del Sacro Cuore, Dipartimento Universitario Diagnostica per Immagini,. Radioterapia Oncologica Ed Ematologia, Roma, Italy; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica Ed Ematologia, Roma, Italy.
²⁷ Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
²⁸ Department of Surgery, Siena University Hospital, University of Siena, Siena, Italy.
²⁹ General and Upper GI Division, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
³⁰ Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
³¹ Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
³² Department of Gastroenterology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³³ Department of Medical Oncology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³⁴ Department of Surgery, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³⁵ Department of Radiation Oncology, Radiotherapiegroep, Deventer, the Netherlands.
³⁶ Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
³⁷ Department of Medical Oncology, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
³⁸ Department of Radiation Oncology, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
³⁹ Department of Surgery, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
⁴⁰ Department of Medical Oncology, Catharina Medical Center, Eindhoven, the Netherlands.
⁴¹ Department of Radiation Oncology, Catharina Medical Center, Eindhoven, the Netherlands.
⁴² Department of Surgery, Catharina Medical Center, Eindhoven, the Netherlands.
⁴³ Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
⁴⁴ Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
⁴⁵ Department of Surgery, Erasmus University Medical Center, University of Rotterdam, Rotterdam, the Netherlands.
⁴⁶ Department of Medical Oncology, Elisabeth Tweesteden Ziekenhuis Tilburg, the Netherlands.
⁴⁷ Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁴⁸ Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁴⁹ Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁵⁰ Department of Surgery Jagiellonian University Medical College, Krakow, Poland.
⁵¹ Department of Surgical Oncology, Medical University of Lublin, Lublin, Poland.
⁵² Department of Oncology and Radiotherapy, Maria Skłodowska-Curie Institute, Warsaw, Poland.
⁵³ Department of Medical Oncology, Hospital Universitari Vall D'Hebron and Vall D'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
⁵⁴ Department of Surgery, Hospital Del Mar, Universitat Autònoma de Barcelona, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, Spain.
⁵⁵ Department of Medical Oncology, Hospital Clinico Universitario de Valencia, University of Valencia, Incliva Biomedical Research Institute, Valencia, Spain.
⁵⁶ Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, And Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden.
⁵⁷ Department of Surgery, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
⁵⁸ Department of Medical Oncology, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
⁵⁹ Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁶⁰ Department of Upper Gastrointestinal Surgery, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham, Birmingham, United Kingdom.
⁶¹ Department of Oncology, Cambridge University Hospitals, Cambridge University, Cambridge, United Kingdom.
⁶² Department of Surgery, Imperial College London, London University, London, United Kingdom.
⁶³ Department of Surgery, Royal Marsden Hospital, London University, London, United Kingdom.
⁶⁴ Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
⁶⁵ Department of Upper GI Surgery, Norfolk & Norwich University Hospital NHS Foundation Trust, Norwich, United Kingdom.
⁶⁶ Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: p.s.n.vanrossum@amsterdamumc.nl.

PMID: 36947929
DOI: 10.1016/j.ejca.2023.02.015

Free article

Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

Tiuri E Kroese et al. Eur J Cancer. 2023 May.

Free article

. 2023 May:185:28-39.

doi: 10.1016/j.ejca.2023.02.015. Epub 2023 Feb 24.

Authors

Collaborators

OMEC collaborators:
Tom Rozema, Joos Heisterkamp, Markus Schaefer, Esat-Mahmut Ozsahin, Jacco de Haan, Jan Willem van den Berg, Frederic Duprez, Eduard Callebout, Elke van Daele, Ulrich Hacker, Albrecht Hoffmeister, Thomas Kuhnt, Timm Denecke, Regine Kluge, Gerald Prager, A Ilhan-Mutlu, Dajana Cuicchi, Andrea Ardizzoni, Camiel Rosman, Elske C Gootjes, Heidi Rütten, Francesco Puccetti, Stefano Cascinu, Najla Slim, Maria Eugenia Barrios, Maria Carmen Fernandez, Roberto Martí-Oriol, Marisol Huerta Alvaro, Almudena Vera, Esther Jordá, Fernando L Mozos, Anna Reig, Laura Visa, Bogumiła Ciseł, Joanna Czechowska, Magdalena Kwietniewska, Agnieszka Pikuła, Magdalena Skórzewska, Aleksandra Kozłowska, Karol Rawicz-Pruszyński

Affiliations

¹ Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: https://twitter.com/TEKroese.
² Amsterdam UMC Location University of Amsterdam, Department of Medical Oncology, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
³ Department of Surgery, Medical University of Vienna, Vienna University, Vienna, Austria.
⁴ Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
⁵ Department of Medical Oncology, KU Leuven, Leuven University, Leuven, Belgium.
⁶ Department of Radiation Oncology, KU Leuven, Leuven University, Leuven, Belgium.
⁷ Department of Surgery, KU Leuven, Leuven University, Leuven, Belgium.
⁸ Department of Radiation Oncology, AZ Sint Maarten, Mechelen, Belgium.
⁹ Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk, University Brno, Brno, Czech Republic.
¹⁰ Danish Center of Particle Therapy, Aarhus University Medical Center, Aarhus University, Aarhus, Denmark.
¹¹ Department of Radiation Oncology, Aarhus University Medical Center, Aarhus University, Aarhus, Denmark.
¹² Department of Medical Oncology, Odense University Medical Center, University of Odense, Odense, Denmark.
¹³ Department of Medical Oncology, Tallinn University Hospital, Tallinn University, Tallinn, Estonia.
¹⁴ Department of Medical Oncology, IRCM, Inserm, Université Montpellier, ICM, Montpellier, France.
¹⁵ Department of Surgery, Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
¹⁶ Department of Surgery, University Hospital Cologne, University of Cologne, Cologne, Germany.
¹⁷ Department of Medical Oncology, University Hospital Leipzig, University of Leipzig, Leipzig Germany.
¹⁸ Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, University of Leipzig, Leipzig Germany.
¹⁹ Department of Medicine, Johannes Gutenberg-University Clinic, University of Mainz, Mainz, Germany.
²⁰ Department of Radiation Oncology, University Hospital Tubingen, University of Tubingen, Tubingen, Germany.
²¹ Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
²² Department of Surgery, St. James Hospital, Trinity College Dublin, Dublin, Ireland.
²³ Department of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Radiation Oncology, DIMES, Alma Mater Studiorum - Bologna University, Bologna, Italy.
²⁴ Department of GI Surgery, San Raffaele Hospital, San Raffaele Vita-salute University, Milan, Italy.
²⁵ Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; Upper GI and General Surgery Division, Department of Surgery IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
²⁶ Università Cattolica Del Sacro Cuore, Dipartimento Universitario Diagnostica per Immagini,. Radioterapia Oncologica Ed Ematologia, Roma, Italy; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica Ed Ematologia, Roma, Italy.
²⁷ Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
²⁸ Department of Surgery, Siena University Hospital, University of Siena, Siena, Italy.
²⁹ General and Upper GI Division, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
³⁰ Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
³¹ Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
³² Department of Gastroenterology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³³ Department of Medical Oncology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³⁴ Department of Surgery, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³⁵ Department of Radiation Oncology, Radiotherapiegroep, Deventer, the Netherlands.
³⁶ Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
³⁷ Department of Medical Oncology, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
³⁸ Department of Radiation Oncology, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
³⁹ Department of Surgery, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
⁴⁰ Department of Medical Oncology, Catharina Medical Center, Eindhoven, the Netherlands.
⁴¹ Department of Radiation Oncology, Catharina Medical Center, Eindhoven, the Netherlands.
⁴² Department of Surgery, Catharina Medical Center, Eindhoven, the Netherlands.
⁴³ Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
⁴⁴ Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
⁴⁵ Department of Surgery, Erasmus University Medical Center, University of Rotterdam, Rotterdam, the Netherlands.
⁴⁶ Department of Medical Oncology, Elisabeth Tweesteden Ziekenhuis Tilburg, the Netherlands.
⁴⁷ Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁴⁸ Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁴⁹ Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁵⁰ Department of Surgery Jagiellonian University Medical College, Krakow, Poland.
⁵¹ Department of Surgical Oncology, Medical University of Lublin, Lublin, Poland.
⁵² Department of Oncology and Radiotherapy, Maria Skłodowska-Curie Institute, Warsaw, Poland.
⁵³ Department of Medical Oncology, Hospital Universitari Vall D'Hebron and Vall D'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
⁵⁴ Department of Surgery, Hospital Del Mar, Universitat Autònoma de Barcelona, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, Spain.
⁵⁵ Department of Medical Oncology, Hospital Clinico Universitario de Valencia, University of Valencia, Incliva Biomedical Research Institute, Valencia, Spain.
⁵⁶ Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, And Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden.
⁵⁷ Department of Surgery, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
⁵⁸ Department of Medical Oncology, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
⁵⁹ Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁶⁰ Department of Upper Gastrointestinal Surgery, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham, Birmingham, United Kingdom.
⁶¹ Department of Oncology, Cambridge University Hospitals, Cambridge University, Cambridge, United Kingdom.
⁶² Department of Surgery, Imperial College London, London University, London, United Kingdom.
⁶³ Department of Surgery, Royal Marsden Hospital, London University, London, United Kingdom.
⁶⁴ Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
⁶⁵ Department of Upper GI Surgery, Norfolk & Norwich University Hospital NHS Foundation Trust, Norwich, United Kingdom.
⁶⁶ Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: p.s.n.vanrossum@amsterdamumc.nl.

PMID: 36947929
DOI: 10.1016/j.ejca.2023.02.015

Abstract

Background: Local treatment improves the outcomes for oligometastatic disease (OMD, i.e. an intermediate state between locoregional and widespread disseminated disease). However, consensus about the definition, diagnosis and treatment of oligometastatic oesophagogastric cancer is lacking. The aim of this study was to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophagogastric cancer.

Methods: In total, 65 specialists in the multidisciplinary treatment for oesophagogastric cancer from 49 expert centres across 16 European countries were requested to participate in this Delphi study. The consensus finding process consisted of a starting meeting, 2 online Delphi questionnaire rounds and an online consensus meeting. Input for Delphi questionnaires consisted of (1) a systematic review on definitions of oligometastatic oesophagogastric cancer and (2) a discussion of real-life clinical cases by multidisciplinary teams. Experts were asked to score each statement on a 5-point Likert scale. The agreement was scored to be either absent/poor (<50%), fair (50%-75%) or consensus (≥75%).

Results: A total of 48 experts participated in the starting meeting, both Delphi rounds, and the consensus meeting (overall response rate: 71%). OMD was considered in patients with metastatic oesophagogastric cancer limited to 1 organ with ≤3 metastases or 1 extra-regional lymph node station (consensus). In addition, OMD was considered in patients without progression at restaging after systemic therapy (consensus). For patients with synchronous or metachronous OMD with a disease-free interval ≤2 years, systemic therapy followed by restaging to consider local treatment was considered as treatment (consensus). For metachronous OMD with a disease-free interval >2 years, either upfront local treatment or systemic treatment followed by restaging was considered as treatment (fair agreement).

Conclusion: The OMEC project has resulted in a multidisciplinary European consensus statement for the definition, diagnosis and treatment of oligometastatic oesophagogastric adenocarcinoma and squamous cell cancer. This can be used to standardise inclusion criteria for future clinical trials.

Keywords: Gastric cancer; Metastasectomy; Metastasis; Oesophageal cancer; Oligometastasis; Stereotactic body radiotherapy.

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Conflict of interest statement

Conflict of interest statement The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. van Laarhoven reports grants or advisory/speaker role from: Astellas, BMS, Dragonfly, Lilly, Merck, Novartis, Nordic Pharma, Servier; research funding or medical supply from: Bayer, BMS, Celgene, Janssen, Incyte, Lilly, Merck, Nordic Pharma, Philips, Roche, Servier; and has received unrestricted research funding (non-commercial) from: Dutch Cancer Society, NWO/ZonMw, European Research Council, MaagLeverDarm Stichting. Dr. Muijs reports institutional grants from: Elekta, IBA, RaySearch, Siemens, Mirada, Bergoz Instrumentation and Medical Data Works, KWF, all outside the submitted work. Dr. van Hillegersberg has a consulting and advisory role at Intuitive Surgical. Dr. de Manzoni reports personal fees from Lilly, outside the submitted work. Dr. Gani reports travel grants from Elekta and departmental research cooperation, outside the submitted work. Dr. Smyth reports personal fees/grants from: Astra Zeneca, Beigene, BMS, Amal Therapeutics, Amgen, Daiichi Sankyo, Merck, Servier, Novartis, Pfizer, Roche, and Zymeworks, all outside the submitted work. Dr. Haj Mohammad reports consulation fees from: Merck, BMS, Eli Lilly, Astra Zeneca, and research funding from Servier, all outside the submitted work. Dr. Adenis reports grants and personal fees from Bayer, personal fees and non-fianciel support from MSD, personal fees from: BMS, Novartis, Pierre-Fabre, non-financial support from Servier, grants from Sanofi, all outside the submitted work. Dr. Lordick reports grants from: BMS and Gilead, personal fees from: Amgen, Astellas, Bayer, BMS, Daiichi Sankyo, Eli Lilly, Elsevier, Incyte, Merck, MSD, Roche, Servier, all outside the submitted work. Dr. Slingerland reports an advisory role at BMS and Lilly. Dr. van Berge Henegouwen received researcher-initiated grant from Stryker and is consultant for Alesi Surgical, Johnson and Johnson, Medtronic, Braun and Mylan. Dr Nilsson reports advisory roles for BMS and Medtronic. All remaining authors have declared no conflict of interest.

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Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

Collaborators

Affiliations

Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

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LinkOut - more resources

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Medical