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. 2023 Jun 1;71(6):451-453.
doi: 10.1248/cpb.c22-00779. Epub 2023 Mar 23.

Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes

Cao Thanh Hai  1   2   3 , Nguyen Thi Luyen  2 , Do Hoang Giang  2 , Bui Quang Minh  2 , Nguyen Quang Trung  2 , Pham The Chinh  3 , Dang Viet Hau  1   2 , Nguyen Tien Dat  1   2
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Free article

Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes

Cao Thanh Hai et al. Chem Pharm Bull (Tokyo). .
Free article

Abstract

Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using one-dimensional (1D) and 2D-NMR spectra and high resolution electrospray ionization (HR-ESI)-MS data. Compound 5 exhibited the most active anti-inflammatory activity with IC50 values of 27.5 µM in inhibiting of nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.

Keywords: Atractylodes macrocephala; anti-inflammation; atractylenolide III; eudesmane; secoatractylolactone.

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