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Comment
. 2023 Apr;103(4):656-658.
doi: 10.1016/j.kint.2022.12.019.

Fosl1: friend or foe?

Shruti Bhargava  1 , Joachim Jankowski  2
Affiliations
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Fosl1: friend or foe?

Shruti Bhargava et al. Kidney Int. 2023 Apr.

Abstract

Fos-like antigen 1 (Fosl1) is a protein that belongs to the Fos family of transcription factors. Fosl1 has an impact on (i) carcinogenesis, (ii) acute kidney injury, and (iii) fibroblast growth factor expression. Recently, the nephroprotective effect of Fosl1 by the preservation of Klotho expression was recently identified. The identification of a link between Fosl1 and Klotho expression provides an entirely new field of nephroprotection.

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