Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023:1411:3-15.
doi: 10.1007/978-981-19-7376-5_1.

Neuron-Microglia Crosstalk in Neuropsychiatric Disorders

Sang Won Jeon  1 , Yong-Ku Kim  2
Affiliations
Review

Neuron-Microglia Crosstalk in Neuropsychiatric Disorders

Sang Won Jeon et al. Adv Exp Med Biol. 2023.

Abstract

Numerous studies have investigated the causes and mechanisms of psychiatric disorders through postmortem examination of patients with a history of a schizophrenia, mood disorder, or neurocognitive disorder. In addition, the search for specific mechanism-based treatments for psychiatric disorders has been intensified through the use of transgenic animal models involving specific genes tightly associated with psychiatric disorders. As a result, many studies with patients or animal models have reported a close association of neuroglia with major psychiatric disorders. Recently, research has focused on the associations between microglia and major psychiatric disorders and on the role of the immune response and abnormal microglia in the onset and symptoms of psychiatric disorders, in particular. Postmortem studies of brain tissue and animal models recapitulating human mental disorders have also confirmed association between psychiatric disorders and quantitative, structural, or functional abnormalities of neuron-microglia crosstalk. This review aims to describe the relationships between microglia and major psychiatric disorders and to specifically examine studies of gene expression and function of microglia in depression, schizophrenia, and Alzheimer's disease.

Keywords: Alzheimer’s disease; Depression; Microglia; Neuroglia; Neuron; Schizophrenia.

PubMed Disclaimer

References

    1. Funk GD, Rajani V, Alvares TS, Revill AL, Zhang Y, Chu NY, et al. Neuroglia and their roles in central respiratory control; an overview. Comp Biochem Physiol A Mol Integr Physiol. 2015;186:83–95. - PubMed - DOI
    1. Nishiyama A, Komitova M, Suzuki R, Zhu X. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci. 2009;10(1):9–22. - PubMed - DOI
    1. Gundersen V, Storm-Mathisen J, Bergersen LH. Neuroglial transmission. Physiol Rev. 2015;95(3):695–726. - PubMed - DOI
    1. Stevenson JA, Yoon MG. Mitosis of radial glial cells in the optic tectum of adult goldfish. J Neurosci. 1981;1(8):862–75. - PubMed - PMC - DOI
    1. Takebayashi M. Psychiatric disorders from a perspective of glia. Seishin Shinkeigaku Zasshi. 2013;115(12):1186–93. - PubMed

LinkOut - more resources