. 2023 Mar 23;23(1):265.

doi: 10.1186/s12885-023-10708-6.

Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

Douglas B Johnson¹, Michael B Atkins², Cassandra Hennessy³, Trisha Wise-Draper⁴, Hannah Heilman⁴, Joy Awosika⁴, Ziad Bakouny⁵, Chris Labaki⁵, Renee Maria Saliby⁵, Clara Hwang⁶, Sunny R K Singh⁶, Nino Balanchivadze⁶, Christopher R Friese⁷, Leslie A Fecher⁷, James J Yoon⁷, Brandon Hayes-Lattin⁸, Mehmet A Bilen⁹, Cecilia A Castellano⁹, Gary H Lyman¹⁰, Lisa Tachiki¹⁰, Sumit A Shah¹¹, Michael J Glover¹¹, Daniel B Flora¹², Elizabeth Wulff-Burchfield¹³, Anup Kasi¹³, Saqib H Abbasi¹³, Dimitrios Farmakiotis¹⁴, Kendra Viera¹⁴, Elizabeth J Klein¹⁴, Lisa B Weissman¹⁵, Chinmay Jani¹⁵, Matthew Puc¹⁶, Catherine C Fahey³, Daniel Y Reuben¹⁷, Sanjay Mishra³, Alicia Beeghly-Fadiel³, Benjamin French³, Jeremy L Warner^{3

14}; COVID-19 and Cancer Consortium

Collaborators, Affiliations

Collaborators

COVID-19 and Cancer Consortium:
Sonya A Reid, Alaina J Brown, Alex Cheng, Sarah Croessmann, Elizabeth J Davis, Kyle T Enriquez, Erin A Gillaspie, Daniel Hausrath, Xuanyi Li, David A Slosky, Carmen C Solorzano, Matthew D Tucker, Karen Vega-Luna, Lucy L Wang, Trisha M Wise-Draper, Syed A Ahmad, Punita Grover, Shuchi Gulati, Jordan Kharofa, Tahir Latif, Michelle Marcum, Davendra P S Sohal, Olga Zamulko, Toni K Choueiri, Jean M Connors, George D Demetri, Narjust Duma, Dory A Freeman, Antonio Giordano, Alicia K Morgans, Anju Nohria, Renee-Maria Saliby, Andrew L Schmidt, Eliezer M Van Allen, Wenxin Xu, Rebecca L Zon, Shirish M Gadgeel, Sheela Tejwani, Anne Boldt, Aaron M Cohen, Shannon McWeeney, Eneida R Nemecek, Staci P Williamson, Deepak Ravindranathan, Jerome J Graber, Petros Grivas, Jessica E Hawley, Elizabeth T Loggers, Ryan C Lynch, Elizabeth S Nakasone, Michael T Schweizer, Shaveta Vinayak, Michael J Wagner, Albert Yeh, Elwyn C Cabebe, Michael J Glover, Alokkumar Jha, Ali Raza Khaki, Lidia Schapira, Julie Tsu-Yu Wu, Goetz Kloecker, Barbara B Logan, Chaitanya Mandapakala, Crosby D Rock, Panos Arvanitis, Pamela C Egan, Hina Khan, Adam J Olszewski, Kendra Vieira, Lisa B Weissmann, Padmanabh S Bhatt, Melissa G Mariano, Carey C Thomson, Theresa M Carducci, Karen J Goldsmith, Susan Van Loon, Mariam Alexander, Sara Matar, Sarah Mushtaq, Keith E Stockerl-Goldstein, Omar Butt, Mark A Fiala, Jeffrey P Henderson, Ryan S Monahan, Alice Y Zhou, Philip E Lammers, Sanjay G Revankar, Salvatore A Del Prete, Michael H Bar, Anthony P Gulati, K M Steve Lo, Suzanne J Rose, Jamie Stratton, Paul L Weinstein, Shilpa Gupta, Nathan A Pennell, Manmeet S Ahluwalia, Scott J Dawsey, Christopher A Lemmon, Amanda Nizam, Nima Sharifi, Claire Hoppenot, Ang Li, Susan Halabi, Hannah Dzimitrowicz, Tian Zhang, Sharad Goyal, Minh-Phuong Huynh-Le, Peter Paul Yu, Jessica M Clement, Ahmad Daher, Mark E Dailey, Rawad Elias, Asha Jayaraj, Emily Hsu, Alvaro G Menendez, Oscar K Serrano, Melissa K Accordino, Divaya Bhutani, Dawn Hershman, Matthew A Ingham, Gary K Schwartz, Eric H Bernicker, John F Deeken, Danielle Shafer, Erika Ruíz-García, Ana Ramirez, Diana Vilar-Compte, Mark A Lewis, Terence D Rhodes, David M Gill, Clarke A Low, Sandeep H Mashru, Abdul-Hai Mansoor, Grant C Lewis, Stephanie J Smith, Howard A Zaren, Gayathri Nagaraj, Mojtaba Akhtari, Dan R Castillo, Eric Lau, Mark E Reeves, Stephanie Berg, Natalie Knox, Timothy E O'Connor, Eric B Durbin, Amit A Kulkarni, Heather H Nelson, Zohar Sachs, Rachel P Rosovsky, Kerry L Reynolds, Aditya Bardia, Genevieve Boland, Justin F Gainor, Leyre Zubiri, Thorvardur R Halfdanarson, Tanios S Bekaii-Saab, Aakash Desai, Irbaz B Riaz, Surbhi Shah, Katherine E Smith, Colt Williams, Nathaniel Bouganim, Arielle Elkrief, Justin Panasci, Donald C Vinh, Gregory J Riely, Rimma Belenkaya, John Philip, Bryan Faller, Rana R McKay, Archana Ajmera, Sharon S Brouha, Sharon Choi, Albert Hsiao, Seth Kligerman, Taylor K Nonato, Erin G Reid Sibel Blau, Sachin R Jhawar, Daniel Addison, James L Chen, Margaret E Gatti-Mays, Vidhya Karivedu, Vidhya Karivedu, Joshua D Palmer, Daniel G Stover, Sarah Wall, Nicole O Williams, Monika Joshi, Hyma V Polimera, Lauren D Pomerantz, Marc A Rovito, Elizabeth A Griffiths, Pragati G Advani, Igor Puzanov, Salma K Jabbour, Christian F Misdary, Mansi R Shah, Gerald Batist, Erin Cook, Miriam Santos Dutra, Cristiano Ferrario, Wilson H Miller Jr, Babar Bashir, Christopher McNair, Sana Z Mahmood, Vasil Mico, Andrea Verghese Rivera, Natasha C Edwin, Melissa Smits, Deborah B Doroshow, Matthew D Galsky, Michael Wotman, Alyson Fazio, Julie C Fu, Kathryn E Huber, Mark H Sueyoshi, Vadim S Koshkin, Hala T Borno, Daniel H Kwon, Eric J Small, Sylvia Zhang, Samuel M Rubinstein, William A Wood, Tessa M Andermann, Christopher Jensen, Daniel W Bowles, Christoper L Geiger, Lawrence E Feldman, Kent F Hoskins, Gerald Gantt Jr, Li C Liu, Mahir Khan, Ryan H Nguyen, Mary Pasquinelli, Candice Schwartz, Neeta K Venepalli, Blanche H Mavromatis, Ragneel R Bijjula, Qamar U Zaman, David M Aboulafiam, Brett A Schroeder, Umit Topaloglu, Saif I Alimohamed, Joan K Moore, Prakash Peddi, Lane R Rosen, Briana Barrow McCollough, Navid Hafez, Roy Herbst, Patricia LoRusso, Maryam B Lustberg, Tyler Masters, Catherine Stratton

Affiliations

¹ Vanderbilt University Medical Center, Nashville, TN, 37232, USA. douglas.b.johnson@vumc.org.
² Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
³ Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
⁴ University of Cincinnati Cancer Center, Cincinnati, USA.
⁵ Dana-Farber Cancer Institute, Boston, MA, USA.
⁶ Henry Ford Cancer Institute, Henry Ford Hospital, Detroit, MI, USA.
⁷ University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
⁸ Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
⁹ Winship Cancer Institute, Emory University, Atlanta, GA, USA.
¹⁰ Fred Hutchinson Cancer Center, Seattle, WA, USA.
¹¹ Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
¹² St. Elizabeth Healthcare, Edgewood, KY, USA.
¹³ The University of Kansas Cancer Center, Lawrence, KS, USA.
¹⁴ Brown University and Lifespan Cancer Institute, Providence, Rhode Island, USA.
¹⁵ Mount Auburn Hospital, Cambridge, MA, USA.
¹⁶ Virtua Health, Marlton, NJ, USA.
¹⁷ Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

PMID: 36949413
PMCID: PMC10033295
DOI: 10.1186/s12885-023-10708-6

Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

Douglas B Johnson et al. BMC Cancer. 2023.

. 2023 Mar 23;23(1):265.

doi: 10.1186/s12885-023-10708-6.

Authors

Collaborators

COVID-19 and Cancer Consortium:
Sonya A Reid, Alaina J Brown, Alex Cheng, Sarah Croessmann, Elizabeth J Davis, Kyle T Enriquez, Erin A Gillaspie, Daniel Hausrath, Xuanyi Li, David A Slosky, Carmen C Solorzano, Matthew D Tucker, Karen Vega-Luna, Lucy L Wang, Trisha M Wise-Draper, Syed A Ahmad, Punita Grover, Shuchi Gulati, Jordan Kharofa, Tahir Latif, Michelle Marcum, Davendra P S Sohal, Olga Zamulko, Toni K Choueiri, Jean M Connors, George D Demetri, Narjust Duma, Dory A Freeman, Antonio Giordano, Alicia K Morgans, Anju Nohria, Renee-Maria Saliby, Andrew L Schmidt, Eliezer M Van Allen, Wenxin Xu, Rebecca L Zon, Shirish M Gadgeel, Sheela Tejwani, Anne Boldt, Aaron M Cohen, Shannon McWeeney, Eneida R Nemecek, Staci P Williamson, Deepak Ravindranathan, Jerome J Graber, Petros Grivas, Jessica E Hawley, Elizabeth T Loggers, Ryan C Lynch, Elizabeth S Nakasone, Michael T Schweizer, Shaveta Vinayak, Michael J Wagner, Albert Yeh, Elwyn C Cabebe, Michael J Glover, Alokkumar Jha, Ali Raza Khaki, Lidia Schapira, Julie Tsu-Yu Wu, Goetz Kloecker, Barbara B Logan, Chaitanya Mandapakala, Crosby D Rock, Panos Arvanitis, Pamela C Egan, Hina Khan, Adam J Olszewski, Kendra Vieira, Lisa B Weissmann, Padmanabh S Bhatt, Melissa G Mariano, Carey C Thomson, Theresa M Carducci, Karen J Goldsmith, Susan Van Loon, Mariam Alexander, Sara Matar, Sarah Mushtaq, Keith E Stockerl-Goldstein, Omar Butt, Mark A Fiala, Jeffrey P Henderson, Ryan S Monahan, Alice Y Zhou, Philip E Lammers, Sanjay G Revankar, Salvatore A Del Prete, Michael H Bar, Anthony P Gulati, K M Steve Lo, Suzanne J Rose, Jamie Stratton, Paul L Weinstein, Shilpa Gupta, Nathan A Pennell, Manmeet S Ahluwalia, Scott J Dawsey, Christopher A Lemmon, Amanda Nizam, Nima Sharifi, Claire Hoppenot, Ang Li, Susan Halabi, Hannah Dzimitrowicz, Tian Zhang, Sharad Goyal, Minh-Phuong Huynh-Le, Peter Paul Yu, Jessica M Clement, Ahmad Daher, Mark E Dailey, Rawad Elias, Asha Jayaraj, Emily Hsu, Alvaro G Menendez, Oscar K Serrano, Melissa K Accordino, Divaya Bhutani, Dawn Hershman, Matthew A Ingham, Gary K Schwartz, Eric H Bernicker, John F Deeken, Danielle Shafer, Erika Ruíz-García, Ana Ramirez, Diana Vilar-Compte, Mark A Lewis, Terence D Rhodes, David M Gill, Clarke A Low, Sandeep H Mashru, Abdul-Hai Mansoor, Grant C Lewis, Stephanie J Smith, Howard A Zaren, Gayathri Nagaraj, Mojtaba Akhtari, Dan R Castillo, Eric Lau, Mark E Reeves, Stephanie Berg, Natalie Knox, Timothy E O'Connor, Eric B Durbin, Amit A Kulkarni, Heather H Nelson, Zohar Sachs, Rachel P Rosovsky, Kerry L Reynolds, Aditya Bardia, Genevieve Boland, Justin F Gainor, Leyre Zubiri, Thorvardur R Halfdanarson, Tanios S Bekaii-Saab, Aakash Desai, Irbaz B Riaz, Surbhi Shah, Katherine E Smith, Colt Williams, Nathaniel Bouganim, Arielle Elkrief, Justin Panasci, Donald C Vinh, Gregory J Riely, Rimma Belenkaya, John Philip, Bryan Faller, Rana R McKay, Archana Ajmera, Sharon S Brouha, Sharon Choi, Albert Hsiao, Seth Kligerman, Taylor K Nonato, Erin G Reid Sibel Blau, Sachin R Jhawar, Daniel Addison, James L Chen, Margaret E Gatti-Mays, Vidhya Karivedu, Vidhya Karivedu, Joshua D Palmer, Daniel G Stover, Sarah Wall, Nicole O Williams, Monika Joshi, Hyma V Polimera, Lauren D Pomerantz, Marc A Rovito, Elizabeth A Griffiths, Pragati G Advani, Igor Puzanov, Salma K Jabbour, Christian F Misdary, Mansi R Shah, Gerald Batist, Erin Cook, Miriam Santos Dutra, Cristiano Ferrario, Wilson H Miller Jr, Babar Bashir, Christopher McNair, Sana Z Mahmood, Vasil Mico, Andrea Verghese Rivera, Natasha C Edwin, Melissa Smits, Deborah B Doroshow, Matthew D Galsky, Michael Wotman, Alyson Fazio, Julie C Fu, Kathryn E Huber, Mark H Sueyoshi, Vadim S Koshkin, Hala T Borno, Daniel H Kwon, Eric J Small, Sylvia Zhang, Samuel M Rubinstein, William A Wood, Tessa M Andermann, Christopher Jensen, Daniel W Bowles, Christoper L Geiger, Lawrence E Feldman, Kent F Hoskins, Gerald Gantt Jr, Li C Liu, Mahir Khan, Ryan H Nguyen, Mary Pasquinelli, Candice Schwartz, Neeta K Venepalli, Blanche H Mavromatis, Ragneel R Bijjula, Qamar U Zaman, David M Aboulafiam, Brett A Schroeder, Umit Topaloglu, Saif I Alimohamed, Joan K Moore, Prakash Peddi, Lane R Rosen, Briana Barrow McCollough, Navid Hafez, Roy Herbst, Patricia LoRusso, Maryam B Lustberg, Tyler Masters, Catherine Stratton

Affiliations

¹ Vanderbilt University Medical Center, Nashville, TN, 37232, USA. douglas.b.johnson@vumc.org.
² Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
³ Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
⁴ University of Cincinnati Cancer Center, Cincinnati, USA.
⁵ Dana-Farber Cancer Institute, Boston, MA, USA.
⁶ Henry Ford Cancer Institute, Henry Ford Hospital, Detroit, MI, USA.
⁷ University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
⁸ Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
⁹ Winship Cancer Institute, Emory University, Atlanta, GA, USA.
¹⁰ Fred Hutchinson Cancer Center, Seattle, WA, USA.
¹¹ Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
¹² St. Elizabeth Healthcare, Edgewood, KY, USA.
¹³ The University of Kansas Cancer Center, Lawrence, KS, USA.
¹⁴ Brown University and Lifespan Cancer Institute, Providence, Rhode Island, USA.
¹⁵ Mount Auburn Hospital, Cambridge, MA, USA.
¹⁶ Virtua Health, Marlton, NJ, USA.
¹⁷ Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

PMID: 36949413
PMCID: PMC10033295
DOI: 10.1186/s12885-023-10708-6

Abstract

Introduction: COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy.

Methods: Using the COVID-19 and Cancer Consortium (CCC19) registry, we identified 307 patients with melanoma diagnosed with COVID-19. We used multivariable models to assess demographic, cancer-related, and treatment-related factors associated with COVID-19 severity on a 6-level ordinal severity scale. We assessed whether treatment was associated with increased cardiac or pulmonary dysfunction among hospitalized patients and assessed mortality among patients with a history of melanoma compared with other cancer survivors.

Results: Of 307 patients, 52 received immunotherapy (17%), and 32 targeted therapy (10%) in the previous 3 months. Using multivariable analyses, these treatments were not associated with COVID-19 severity (immunotherapy OR 0.51, 95% CI 0.19 - 1.39; targeted therapy OR 1.89, 95% CI 0.64 - 5.55). Among hospitalized patients, no signals of increased cardiac or pulmonary organ dysfunction, as measured by troponin, brain natriuretic peptide, and oxygenation were noted. Patients with a history of melanoma had similar 90-day mortality compared with other cancer survivors (OR 1.21, 95% CI 0.62 - 2.35).

Conclusions: Melanoma therapies did not appear to be associated with increased severity of COVID-19 or worsening organ dysfunction. Patients with history of melanoma had similar 90-day survival following COVID-19 compared with other cancer survivors.

Keywords: COVID-19; Cancer; Immune therapy; Melanoma; Targeted therapy.

PubMed Disclaimer

Conflict of interest statement

DBJ has served on advisory boards or as a consultant for BMS, Catalyst Biopharma, Iovance, Jansen, Mallinckrodt, Merck, Mosaic ImmunoEngineering, Novartis, Oncosec, Pfizer, Targovax, and Teiko, and has received research funding from BMS and Incyte. CRF has received institutional research support from the Merck Foundation and the National Comprehensive Cancer Network (via Pfizer). DF has received research support from Astellas, Viracor, and Merck, and consultant fee from Viracor. LAF has received clinical trial funding from BMS, Kartos, Array-Pfizer, EMD Serono, and as a consultant for Elsevier. GHL reports research grant support from Amgen to the Fred Hutchinson Cancer Center and consulting fees from Beyond Spring, G1 Therapeutics, Partner Therapeutics, Squibb, Samsung Bioepis, Merck, Jazz, TEVA, Seattle Genetics and Frensenius Kabi. Other authors declare no conflicts of interest relevant to the work.

Figures

**Fig. 1**
Distribution of the ordinal COVID-19 severity outcome, stratified by modality of anti-cancer therapy received within 3 months prior to COVID-19 diagnosis. Note: The ordinal COVID-19 severity outcome was based on a patient’s most severe reported disease status during follow-up (for example, a patient who was hospitalized and later died is included in “Died”). The width of the boxes is proportional to the number of patients who received each anti-cancer therapy; the height of the boxes is proportional to the number of patients in each outcome level. Patient numbers are listed for each outcome level

See this image and copyright information in PMC

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Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

Collaborators

Affiliations

Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

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References

MeSH terms

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LinkOut - more resources

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Medical