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. 2023 Mar 6:10:1123588.
doi: 10.3389/fnut.2023.1123588. eCollection 2023.

Association between sarcopenia and kidney stones in United States adult population between 2011 and 2018

Yifan Zhang  1 , Changxiu Tian  1 , Yidi Wang  1 , Houliang Zhang  1 , Jinliang Ni  1 , Wei Song  1 , Huajuan Shi  2 , Tao Zhang  2 , Changbao Xu  3 , Keyi Wang  1 , Bo Peng  1   2
Affiliations

Association between sarcopenia and kidney stones in United States adult population between 2011 and 2018

Yifan Zhang et al. Front Nutr. .

Abstract

Purpose: To investigate the relationship between kidney stones and sarcopenia in United States adult population between 2011 and 2018.

Materials and methods: We conducted a cross-section study based on the National Health and Nutrition Examination Survey (NHANES) including 39,156 individuals. Sarcopenia was assessed by the sarcopenia index. Association between kidney stones and sarcopenia verified by multiple logistic regression analysis and dose-response curves analysis using restricted cubic spline (RCS) regression. Meanwhile, propensity score matching (PSM) was performed to exclude the effect of confounding variables.

Results: There were 9,472 participants in the study by our accurate enrollment screening process. The odds of kidney stones decreased significantly with the increase of sarcopenia index. Logistic regression analysis showed that sarcopenia expressed significant differences in the participants which suffered kidney stone before PSM (p < 0.001). In model 4, adjusting all relevant covariates shown that adjusted odds ratio (aOR) of the 95% confidence intervals for kidney stones in all participants, age <39 years and age ≥40 years, were, respectively, 1.286 (1.006-1,643), 1.697 (1.065-2.702), and 0.965 (0.700-1.330) for sarcopenia, and p values were 0.044, 0.026, and 0.827. After performing PSM, the aOR of the 95% in modal 4 for kidney stones in all participants and age <40 year were 2.365 (1.598-3.500) and 6.793 (2.619-17.6180), respectively (p < 0.01), and especially the aOR in participants (age ≥40) was 1.771(1.138-2.757) with p value being 0.011.

Conclusion: Sarcopenia was positively related to the potential risk of kidney stones in the United States adult population.

Keywords: NHANES; cross-section study; kidney stones; sarcopenia; sarcopenia index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic flow diagram of inclusion and exclusion criteria for our study cohort.
Figure 2
Figure 2
Relative risk for kidney stones based on sarcopenia index before PSM. The shaded areas represent upper and lower 95% CIs. Adjustment factors are as same as which presented in extended model 4. Restricted cubic spline (RCS) plot of the association between sarcopenia index and kidney stones. The solid and dashed lines represent the odds ratios and 95% confidence intervals.
Figure 3
Figure 3
Distribution of propensity score before and after matching.
Figure 4
Figure 4
Relative risk for kidney stones based on sarcopenia index after PSM. The shaded areas represent upper and lower 95% CIs. Adjustment factors are as same as which presented in extended model 4. Restricted cubic spline (RCS) plot of the association between sarcopenia index and kidney stones. The solid and dashed lines represent the odds ratios and 95% confidence intervals.
See this image and copyright information in PMC

Comment in

  • Urolithiasis/Endourology.
    Assimos DG. Assimos DG. J Urol. 2023 Sep;210(3):560-562. doi: 10.1097/JU.0000000000003574. Epub 2023 Jun 19. J Urol. 2023. PMID: 37334537 No abstract available.

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