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. 2023 Mar 1;16(3):dmm050189.
doi: 10.1242/dmm.050189. Epub 2023 Mar 23.

Redefining tuberculosis: an interview with Lalita Ramakrishnan

Lalita Ramakrishnan  1
Affiliations

Redefining tuberculosis: an interview with Lalita Ramakrishnan

Lalita Ramakrishnan. Dis Model Mech. .

Abstract

Professor Lalita Ramakrishnan is at the forefront of modern tuberculosis (TB) research. She has developed vital tools, most notably a robust zebrafish model, to study this disease, leading to seminal discoveries uncovering bacterial and host interactions throughout infection. Her group has harnessed this knowledge to develop new treatments for TB and shape clinical research. By unveiling these complex interactions, they have also improved our understanding of fundamental biology of macrophages and other infectious diseases, such as leprosy.

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References

    1. Adams, K. N., Takaki, K., Connolly, L. E., Wiedenhoft, H., Winglee, K., Humbert, O., Edelstein, P. H., Cosma, C. L. and Ramakrishnan, L. (2011). Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism. Cell 145, 39-53. 10.1016/j.cell.2011.02.022 - DOI - PMC - PubMed
    1. Adams, K. N., Szumowski, J. D. and Ramakrishnan, L. (2014). Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J. Infect. Dis. 210, 456-466. 10.1093/infdis/jiu095 - DOI - PMC - PubMed
    1. Behr, M. A., Edelstein, P. H. and Ramakrishnan, L. (2018). Revisiting the timetable of tuberculosis. BMJ 362, k2738. 10.1136/bmj.k2738 - DOI - PMC - PubMed
    1. Behr, M. A., Edelstein, P. H. and Ramakrishnan, L. (2019). Is Mycobacterium tuberculosis infection life long? BMJ 367, l5770. 10.1136/bmj.l5770 - DOI - PMC - PubMed
    1. Cambier, C. J., Takaki, K. K., Larson, R. P., Hernandez, R. E., Tobin, D. M., Urdahl, K. B., Cosma, C. L. and Ramakrishnan, L. (2014). Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature 505, 218-222. 10.1038/nature12799 - DOI - PMC - PubMed

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