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Review
. 2023 Sep;43(5):1263-1321.
doi: 10.1002/med.21950. Epub 2023 Mar 23.

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

Milad Ashrafizadeh  1   2 , Chakrabhavi D Mohan  3 , Shobith Rangappa  4 , Ali Zarrabi  2   5 , Kiavash Hushmandi  6 , Alan Prem Kumar  7   8 , Gautam Sethi  7   8 , Kanchugarakoppal S Rangappa  9
Affiliations
Review

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

Milad Ashrafizadeh et al. Med Res Rev. 2023 Sep.

Abstract

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with proliferation, antiapoptosis, survival, and metastasis. STAT3 is overactivated in many human malignancies including GI tumors which accelerates tumor progression, metastasis, and drug resistance. Research in recent years demonstrated that noncoding RNAs (ncRNAs) play a major role in the regulation of many signaling pathways including the STAT3 pathway. The major types of endogenous ncRNAs that are being extensively studied in oncology are microRNAs, long noncoding RNAs, and circular RNAs. These ncRNAs can either be tumor-promoters or tumor-suppressors and each one of them imparts their activity via different mechanisms. The STAT3 pathway is also tightly modulated by ncRNAs. In this article, we have elaborated on the tumor-promoting role of STAT3 signaling in GI tumors. Subsequently, we have comprehensively discussed the oncogenic as well as tumor suppressor functions and mechanism of action of ncRNAs that are known to modulate STAT3 signaling in GI cancers.

Keywords: circRNA; colorectal cancer; esophageal cancer; gastric cancer; liver cancer; lncRNA; miRNA; pancreatic cancer.

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References

REFERENCES

    1. Mohan CD, Rangappa S, Preetham HD, et al. Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature. Semin Cancer Biol. 2020;80:157-182.
    1. Lee JH, Mohan CD, Shanmugam MK, et al. Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway. Biochimie. 2020;175:58-68.
    1. Baburajeev CP, Mohan CD, Patil GS, et al. Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C-N bond formation reactions. RSC Adv. 2016;6(43):36775-36785.
    1. Malojirao VH, Girimanchanaika SS, Shanmugam MK, et al. Novel 1,3,4-oxadiazole targets STAT3 signaling to induce antitumor effect in lung cancer. Biomedicines. 2020;8(9):368.
    1. Mohan CD, Kim C, Siveen KS, et al. Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma. IUBMB Life. 2021;73(11):1348-1362.

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