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Review
. 2023 Jul;19(5):1283-1306.
doi: 10.1007/s12015-023-10523-3. Epub 2023 Mar 23.

Therapeutic Effectiveness of Anticancer Agents Targeting Different Signaling Molecules Involved in Asymmetric Division of Cancer Stem Cell

Priya Samanta #  1 , Arijit Bhowmik #  2 , Souradeep Biswas  1 , Rupali Sarkar  1 , Rituparna Ghosh  1 , Shampa Pakhira  1 , Mrinmoyee Mondal  1 , Soummadeep Sen  1 , Prosenjit Saha  1 , Subhadip Hajra  3
Affiliations
Review

Therapeutic Effectiveness of Anticancer Agents Targeting Different Signaling Molecules Involved in Asymmetric Division of Cancer Stem Cell

Priya Samanta et al. Stem Cell Rev Rep. 2023 Jul.

Abstract

Intra-tumoral heterogeneity is maintained by cancer stem cells (CSCs) with dysregulated self-renewal and asymmetric cell division (ACD). According to the cancer stem cell theory, by ACD a CSC can generate two daughter progenies with different fates such as one cancer stem cell and one differentiated cell. Therefore, this type of mitotic division supports vital process of the maintenance of CSC population. But this CSC pool reservation by ACD complicates the treatment of cancer patients, as CSCs give rise to aggressive clones which are prone to metastasis and drug-insensitivity. Hence, identification of therapeutic modalities which can target ACD of cancer stem cell is an intriguing part of cancer research. In this review, other than the discussion about the extrinsic inducers of ACD role of different proteins, miRNAs and lncRNAs in this type of cell division is also mentioned. Other than these, mode of action of the proven and potential drugs targeting ACD of CSC is also discussed here.

Keywords: Asymmetric division; Cancer stem cell; Drug resistance; Recurrence; Targeted therapy.

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