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Review
. 2024 Jul;52(7):1816-1834.
doi: 10.1007/s10439-023-03176-3. Epub 2023 Mar 23.

3D Bioprinting of Hyaline Cartilage Using Nasal Chondrocytes

Xiaoyi Lan  1 , Yaman Boluk  2 , Adetola B Adesida  3   4
Affiliations
Review

3D Bioprinting of Hyaline Cartilage Using Nasal Chondrocytes

Xiaoyi Lan et al. Ann Biomed Eng. 2024 Jul.

Abstract

Due to the limited self-repair capacity of the hyaline cartilage, the repair of cartilage remains an unsolved clinical problem. Tissue engineering strategy with 3D bioprinting technique has emerged a new insight by providing patient's personalized cartilage grafts using autologous cells for hyaline cartilage repair and regeneration. In this review, we first summarized the intrinsic property of hyaline cartilage in both maxillofacial and orthopedic regions to establish the requirement for 3D bioprinting cartilage tissue. We then reviewed the literature and provided opinion pieces on the selection of bioprinters, bioink materials, and cell sources. This review aims to identify the current challenges for hyaline cartilage bioprinting and the directions for future clinical development in bioprinted hyaline cartilage.

Keywords: 3D bioprinting; Hyaline cartilage; Nasal cartilage; Nasal chondrocytes.

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