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Meta-Analysis
. 2023 Mar 23;18(3):e0282290.
doi: 10.1371/journal.pone.0282290. eCollection 2023.

Risk factors of catheter- associated bloodstream infection: Systematic review and meta-analysis

Elisabeth Lafuente Cabrero  1   2 , Roser Terradas Robledo  2   3 , Anna Civit Cuñado  1 , Diana García Sardelli  1 , Carlota Hidalgo López  4 , Dolors Giro Formatger  3 , Laia Lacueva Perez  2   5 , Cristina Esquinas López  6   7   8 , Avelina Tortosa Moreno  9
Affiliations
Meta-Analysis

Risk factors of catheter- associated bloodstream infection: Systematic review and meta-analysis

Elisabeth Lafuente Cabrero et al. PLoS One. .

Abstract

Introduction: The prevalence of catheter-associated bloodstream infections (CLABSI) is high and is a severe health problem associated with an increase in mortality and elevated economic costs. There are discrepancies related to the risk factors of CLABSI since the results published are very heterogeneous and there is no synthesis in the description of all the predisposing factors.

Objective: We aimed to perform a systematic review and meta-analysis to synthesize and establish the risk factors predisposing to CLABSI reported in the literature.

Method: This is a systematic review of observational studies following the PRISMA recommendations. MEDLINE and CINAHL databases were searched for primary studies from 2007 to 2021. The protocol was registered in PROSPERO CRD42018083564.

Results: A total of 654 studies were identified, 23 of which were included in this systematic review. The meta-analysis included 17 studies and 9 risk factors were analyzed (total parenteral nutrition (TPN), chemotherapy, monolumen and bilumen catheters, days of catheterization, immunosuppression, kidney disease and diabetes mellitus) due to the homogeneity of their definitions and measurements. The risk factors found to increase the probability of developing CLABSI were TPN, multilumen devices, chemotherapy treatment, immunosuppression and the number of days of catheterization. On the other hand, monolumen devices presented a lower likelihood of triggering this infection.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Fig 1
Fig 1. Flow diagram of study selection.
Fig 2
Fig 2. Forest plot of total parenteral nutrition (TPN) and CLABSI.
Fig 3
Fig 3. Forest plot of chemotherapy treatment and CLABSI.
Fig 4
Fig 4. Forest Plot of immune system ompromiso and CLABSI.
Fig 5
Fig 5. Forest Plot of unilumen catheter and CLABSI.
Fig 6
Fig 6. Forest plot of bilumen catheter and CLABSI.
Fig 7
Fig 7. Forest plot of multilumen catheter and CLABSI.
Fig 8
Fig 8. Forest plot of catheter days and CLABSI.
Fig 9
Fig 9. Forest plot of kidney disease and CLABSI.
Fig 10
Fig 10. Forest plot of diabetes mellitus and CLABSI.
See this image and copyright information in PMC

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