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. 2023 Mar 23;18(3):e0282046.
doi: 10.1371/journal.pone.0282046. eCollection 2023.

The socio-demographic, clinical characteristics and outcomes of tuberculosis among HIV infected adults in Lithuania: A thirteen-year analysis

Elzbieta Matulyte  1   2 , Edita Davidaviciene  3 , Zavinta Kancauskiene  4 , Saulius Diktanas  5 , Aidas Kausas  6 , Daiva Velyvyte  7   8 , Jurgita Urboniene  2 , Vilnele Lipnickiene  9 , Megan Laurencikaite  10 , Edvardas Danila  11   12 , Dominique Costagliola  13 , Raimonda Matulionyte  1   2
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The socio-demographic, clinical characteristics and outcomes of tuberculosis among HIV infected adults in Lithuania: A thirteen-year analysis

Elzbieta Matulyte et al. PLoS One. .

Abstract

Background: Tuberculosis (TB) is a public health problem in Lithuania, among the 18 high-priority TB countries in the European region, and the most common AIDS-indicative disease with the highest proportion in the EU/EEA since 2015. The study aimed to identify socio-demographic, clinical characteristics and their relationship with TB outcomes in TB-HIV co-infected patients in Lithuania.

Methods: A retrospective chart review analysed the characteristics of TB-HIV co-infected adults registered in State Information System of Tuberculosis over 2008-2020. The factors associated with drug-resistant TB and unsuccessful treatment outcome were identified by multivariable logistic regression.

Results: The study included 345 cases in 311 patients (239 new, 106 previously treated cases), median age 40 years (IQR 35-45), 80.7% male. 67.8% patients knew their HIV-positive status before TB diagnosis, median time to TB diagnosis was 8 years (IQR 4-12). 83.6% were unemployed, 50.5%-anytime intravenous drug users (IDU), 34.9% abused alcohol. Drug-resistant TB rates in new and previously treated TB cases were 38.1% and 61.3%, respectively. In multivariable analysis, higher risk of drug-resistant TB was associated with imprisonment in new (aOR 3.35; 95%CI 1.17-9.57) and previously treated (aOR 6.63; 95%CI 1.09-40.35) cases. In 52.3% of new TB cases and in 42.5% previously treated TB cases the treatment outcomes were unsuccessful. In multivariable analysis of new TB cases, current imprisonment (aOR 2.77; 95%CI 1.29-5.91) and drug-resistant TB (aOR 2.18; 95%CI 1.11-4.28) were associated with unsuccessful treatment outcome. In multivariable analysis of previously treated TB cases, female gender (aOR 11.93; 95%CI 1.86-76.69), alcohol abuse (aOR 3.17; 95%CI 1.05-9.58), drug-resistant TB (aOR 4.83; 95%CI 1.53-15.28) were associated with unsuccessful treatment outcome.

Conclusions: In the TB-HIV-infected adult cohort in Lithuania, unemployment, imprisonment, IDU, alcohol abuse, known to be risk factors for TB, were very frequent. Drug resistance was an undeniable risk factor for unsuccessful treatment outcome and imprisonment was associated with drug resistant TB.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Dynamics of TB treatment outcomes in TB/HIV cases (n = 345) in Lithuania.
Fig 2
Fig 2. Multivariable analysis of factors associated with drug-resistant TB and unsuccessful treatment outcomes in new TB-HIV cases in Lithuania, 2008–2020 (n = 239).
Fig 3
Fig 3. Multivariable analysis of factors associated with drug-resistant TB and unsuccessful treatment outcomes in previously treated TB-HIV cases in Lithuania, 2008–2020 (n = 106).
See this image and copyright information in PMC

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