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. 2023 Mar-Apr;29(2):89-97.
doi: 10.1097/PPO.0000000000000649.

Microbiome and Diet in Colon Cancer Development and Treatment

Ikuko Kato, Jun Sun

Microbiome and Diet in Colon Cancer Development and Treatment

Ikuko Kato et al. Cancer J. 2023 Mar-Apr.

Abstract

Diet plays critical roles in defining our immune responses, microbiome, and progression of human diseases. With recent progress in sequencing and bioinformatic techniques, increasing evidence indicates the importance of diet-microbial interactions in cancer development and therapeutic outcome. Here, we focus on the epidemiological studies on diet-bacterial interactions in the colon cancer. We also review the progress of mechanistic studies using the experimental models. Finally, we discuss the limits and future directions in the research of microbiome and diet in cancer development and therapeutic outcome. Now, it is clear that microbes can influence the efficacy of cancer therapies. These research results open new possibilities for the diagnosis, prevention, and treatment of cancer. However, there are still big gaps to apply these new findings to the clinical practice.

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Conflict of interest statement

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. This study was supported by the UIC Cancer Center, the NIDDK/National Institutes of Health grant R01 DK105118, R01DK114126, VA Merit Award VA 1 I01 BX004824-01, and DOD BC160450P1 to J.S. The study sponsors play no role in the study design, data collection, analysis, and interpretation of data. The contents do not represent the views of the US Department of Veterans Affairs or the US Government.

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