Disclosure KF reports personal fees for advisory board membership from Curevac and Orion; fees paid to his institution as an invited speaker from Astellas, AstraZeneca, Bayer, Janssen, MSD, Novartis, Pfizer and Sanofi; fees paid to his institution for advisory board membership from AAA, Astellas, AstraZeneca, Bayer, Janssen, MSD, Novartis/AAA and Pfizer; institutional funding as Trial Chair from AstraZeneca, Bayer, Bristol Myers Squibb (BMS), Janssen, MSD, Orion and Pfizer; non-remunerated role as PI and Trial Chair for Bayer, BMS, Merck, Novartis/AAA and Orion. SG reports personal fees for advisory board membership from Amgen, MSD, Orion, Roche and Sanofi; personal speaker honoraria from ESMO, Janssen Cilag, the Swiss Group for Clinical Cancer Research (SAKK) and Swiss Academy of Multidisciplinary Oncology (SAMO) – International Breast Cancer Study Group (IBCSG); personal travel grants from ProteoMEdiX; and other personal honoraria from Radiotelevisione svizzera (RSI; Swiss television). Her institution has received fees for advisory board membership from AAA International, Astellas Pharma, Bayer, BMS, Janssen Cilag, Menarini Silicon Biosystems, Modra Pharmaceuticals Holding B.V., Novartis, Orion, Pfizer, Roche, Telixpharma and Tolero Pharmaceuticals; speaker honoraria from DESO and Silvio Grasso Consulting; a research grant from Astellas and honoraria from Amgen for Steering Committee membership. She has held/holds non-remunerated advisory roles with Aranda, Menarini Silicon Biosystems and ProteoMediX.