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Review
. 2023 Mar;23(2):125-128.
doi: 10.7861/clinmed.2023-0018.

Thyroid disease in pregnancy

Yew Wen Yap  1 , Emeka Onyekwelu  2 , Uazman Alam  3
Affiliations
Review

Thyroid disease in pregnancy

Yew Wen Yap et al. Clin Med (Lond). 2023 Mar.

Abstract

Pregnancy is accompanied by metabolic changes associated with the thyroid gland. It is therefore important to understand the underlying physiological alterations and the management of patients with thyroid disorders in pregnancy. This review focuses on the physiology and the management of hyperthyroidism, hypothyroidism and thyroid nodules in the context of pregnancy.

Keywords: Hypothyroidism in pregnancy; hyperthyroidism in pregnancy; thyroid Stimulating hormone; thyroid nodules in pregnancy.

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Figures

Fig 1
Fig 1
Physiological alterations of thyroid hormones in pregnancy. hCG = human chorionic gonadotrophin; TBG = thyroid binding globulin; TSH = thyroid stimulation hormone.
See this image and copyright information in PMC

References

    1. Jameson JL. McGraw Hill; 2008. Harrison's principles of internal medicine; pp. 2224–2247.
    1. Ain KB, Mori Y, Refetoff S. Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration. J Clin Endocrinol Metab. 1987;65:689–696. - PubMed
    1. 3 De Groot L, Abalovich M, Alexander EK, et al. Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline, J Clin Endocrinol Metab 97:2543–65. - PubMed
    1. Yamazaki K, Sato K, Shizume K, et al. Potent thyrotropic activity of human chorionic gonadotropin variants in terms of 125I incorporation and de novo synthesized thyroid hormone release in human thyroid follicles. J Clin Endocrinol Metab. 1995;80:473–479. - PubMed
    1. Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27:315–389. - PubMed