Reply to 'Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?'

Ana Margarida Pinto^{1

2

3}, Rinie Geenen^{4

5}, Tor D Wager⁶, Mark A Lumley⁷, Winfried Häuser⁸, Eva Kosek^{9

10}, Jacob N Ablin^{11

12}, Kirstine Amris¹³, Jaime Branco^{14

15}, Dan Buskila¹⁶, João Castelhano¹⁷, Miguel Castelo-Branco¹⁷, Leslie J Crofford¹⁸, Mary-Ann Fitzcharles¹⁹, Marina López-Solà²⁰, Mariana Luís²¹, Tiago Reis Marques^{22

23}, Philip J Mease^{24

25}, Filipe Palavra^{26

27}, Jamie L Rhudy²⁸, Lucina Q Uddin²⁹, Paula Castilho¹, Johannes W G Jacobs³⁰, José A P da Silva^{31

32

33}

Affiliations

¹ University of Coimbra, Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), Faculty of Psychology and Educational Sciences, Coimbra, Portugal.
² University of Coimbra, University Clinic of Rheumatology, Faculty of Medicine, Coimbra, Portugal.
³ University of Coimbra, Psychological Medicine Institute, Faculty of Medicine, Coimbra, Portugal.
⁴ Department of Psychology, Utrecht University, Utrecht, The Netherlands.
⁵ Altrecht Psychosomatic Medicine Eikenboom, Zeist, The Netherlands.
⁶ Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
⁷ Department of Psychology, Wayne State University, Detroit, MI, USA.
⁸ Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Munich, Germany.
⁹ Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
¹⁰ Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
¹¹ Internal Medicine H, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
¹² Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
¹³ The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.
¹⁴ Rheumatology Department, Egas Moniz Hospital - Lisboa Ocidental Hospital Centre (CHLO-EPE), Lisbon, Portugal.
¹⁵ Comprehensive Health Research Center (CHRC), Chronic Diseases Research Centre (CEDOC), NOVA Medical School, NOVA University Lisbon (NMS/UNL), Lisbon, Portugal.
¹⁶ Ben Gurion University of the Negev Beer-Sheba, Beersheba, Israel.
¹⁷ University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, Coimbra, Portugal.
¹⁸ Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
¹⁹ Division of Rheumatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
²⁰ Serra Hunter Programme, Department of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, Barcelona, Spain.
²¹ Rheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal.
²² Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital, Imperial College London, London, UK.
²³ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
²⁴ Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, USA.
²⁵ University of Washington School of Medicine, Seattle, WA, USA.
²⁶ Centre for Child Development, Neuropediatric Unit, Paediatric Hospital, Coimbra Hospital and University Centre, Coimbra, Portugal.
²⁷ University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (i.CBR), Faculty of Medicine, Coimbra, Portugal.
²⁸ Department of Psychology, University of Tulsa, Tulsa, OK, USA.
²⁹ Department of Psychology, University of Miami, Coral Gables, FL, USA.
³⁰ Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
³¹ University of Coimbra, University Clinic of Rheumatology, Faculty of Medicine, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.
³² Rheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.
³³ University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (i.CBR), Faculty of Medicine, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.

PMID: 36959282
DOI: 10.1038/s41584-023-00950-4

Comment

Reply to 'Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?'

Ana Margarida Pinto et al. Nat Rev Rheumatol. 2023 May.

. 2023 May;19(5):319-320.

doi: 10.1038/s41584-023-00950-4.

Authors

Affiliations

¹ University of Coimbra, Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), Faculty of Psychology and Educational Sciences, Coimbra, Portugal.
² University of Coimbra, University Clinic of Rheumatology, Faculty of Medicine, Coimbra, Portugal.
³ University of Coimbra, Psychological Medicine Institute, Faculty of Medicine, Coimbra, Portugal.
⁴ Department of Psychology, Utrecht University, Utrecht, The Netherlands.
⁵ Altrecht Psychosomatic Medicine Eikenboom, Zeist, The Netherlands.
⁶ Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
⁷ Department of Psychology, Wayne State University, Detroit, MI, USA.
⁸ Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Munich, Germany.
⁹ Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
¹⁰ Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
¹¹ Internal Medicine H, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
¹² Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
¹³ The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.
¹⁴ Rheumatology Department, Egas Moniz Hospital - Lisboa Ocidental Hospital Centre (CHLO-EPE), Lisbon, Portugal.
¹⁵ Comprehensive Health Research Center (CHRC), Chronic Diseases Research Centre (CEDOC), NOVA Medical School, NOVA University Lisbon (NMS/UNL), Lisbon, Portugal.
¹⁶ Ben Gurion University of the Negev Beer-Sheba, Beersheba, Israel.
¹⁷ University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, Coimbra, Portugal.
¹⁸ Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
¹⁹ Division of Rheumatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
²⁰ Serra Hunter Programme, Department of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, Barcelona, Spain.
²¹ Rheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal.
²² Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital, Imperial College London, London, UK.
²³ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
²⁴ Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, USA.
²⁵ University of Washington School of Medicine, Seattle, WA, USA.
²⁶ Centre for Child Development, Neuropediatric Unit, Paediatric Hospital, Coimbra Hospital and University Centre, Coimbra, Portugal.
²⁷ University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (i.CBR), Faculty of Medicine, Coimbra, Portugal.
²⁸ Department of Psychology, University of Tulsa, Tulsa, OK, USA.
²⁹ Department of Psychology, University of Miami, Coral Gables, FL, USA.
³⁰ Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
³¹ University of Coimbra, University Clinic of Rheumatology, Faculty of Medicine, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.
³² Rheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.
³³ University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (i.CBR), Faculty of Medicine, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.

PMID: 36959282
DOI: 10.1038/s41584-023-00950-4

No abstract available

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Comment on

Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia.
Pinto AM, Geenen R, Wager TD, Lumley MA, Häuser W, Kosek E, Ablin JN, Amris K, Branco J, Buskila D, Castelhano J, Castelo-Branco M, Crofford LJ, Fitzcharles MA, López-Solà M, Luís M, Marques TR, Mease PJ, Palavra F, Rhudy JL, Uddin LQ, Castilho P, Jacobs JWG, da Silva JAP. Pinto AM, et al. Nat Rev Rheumatol. 2023 Jan;19(1):44-60. doi: 10.1038/s41584-022-00873-6. Epub 2022 Dec 5. Nat Rev Rheumatol. 2023. PMID: 36471023 Review.
Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?
Martínez-Lavín M. Martínez-Lavín M. Nat Rev Rheumatol. 2023 May;19(5):318. doi: 10.1038/s41584-023-00949-x. Nat Rev Rheumatol. 2023. PMID: 36959281 No abstract available.

References

1. Pinto, A. M. et al. Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia. Nat. Rev. Rheumatol. 19, 44–60 (2023). - DOI - PubMed
1. Martínez-Lavín, M. Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model? Nat. Rev. Rheumatol. https://doi.org/10.1038/s41584-023-00949-x (2023). - DOI - PubMed
1. Martínez-Lavín, M. Dorsal root ganglia: fibromyalgia pain factory? Clin. Rheumatol. 40, 783–787 (2021). - DOI - PubMed - PMC
1. Martínez-Lavín, M., Infante, O. & Lerma, C. Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies. Semin. Arthritis Rheum. 37, 260–264 (2008). - DOI - PubMed
1. Harte, S. E. et al. Reduced intraepidermal nerve fiber density after a sustained increase in insular glutamate: a proof-of-concept study examining the pathogenesis of small fiber pathology in fibromyalgia. Pain Rep. 2, e590 (2017). - DOI - PubMed - PMC

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Reply to 'Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?'

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Reply to 'Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?'

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