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Review
. 2023 Jun;47(6):423-433.
doi: 10.1038/s41366-023-01291-8. Epub 2023 Mar 23.

Mechanism and treatments of antipsychotic-induced weight gain

Wujie Ye  1 , Jingyu Xing  1 , Zekai Yu  1 , Xingang Hu  2 , Yan Zhao  3
Affiliations
Review

Mechanism and treatments of antipsychotic-induced weight gain

Wujie Ye et al. Int J Obes (Lond). 2023 Jun.

Abstract

The long-term use of antipsychotics (APs) may cause a variety of diseases, such as metabolic syndrome, antipsychotic-induced weight gain (AIWG), and even obesity. This paper reviews the various mechanisms of AIWG and obesity in detail, involving genetics, the central nervous system, the neuroendocrine system, and the gut microbiome. The common drug and non-drug therapies used in clinical practice are also introduced, providing the basis for research on the molecular mechanisms and the future selection of treatments.

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References

    1. Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, et al. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. The Lancet Psychiatry. 2020;7:64–77. - PubMed - PMC - DOI
    1. Grajales D, Vázquez P, Alén R, Hitos AB, Valverde ÁM. Attenuation of Olanzapine-induced endoplasmic reticulum stress improves insulin secretion in pancreatic beta cells. Metabolites. 2022;12:443. - PubMed - PMC - DOI
    1. Mitchell AJ, Vancampfort D, Sweers K, van Winkel R, Yu W, De Hert M. Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders-a systematic review and meta-analysis. Schizophr Bull. 2013;39:306–18. - PubMed - DOI
    1. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2014;384:766–81. - DOI
    1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390:2627–42.

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