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. 2023 Mar 24;11(1):13.
doi: 10.1186/s40635-023-00497-4.

Impact of intravenous fluid administration on cardiac output and oxygenation during cardiopulmonary resuscitation

Jennifer Lutz  1   2 , Yosef Levenbrown  3   4 , Md Jobayer Hossain  5   6 , Anne Hesek  5 , Kelly E Massa  7 , James P Keith  7 , Thomas H Shaffer  2   8   9
Affiliations

Impact of intravenous fluid administration on cardiac output and oxygenation during cardiopulmonary resuscitation

Jennifer Lutz et al. Intensive Care Med Exp. .

Abstract

Background: The effect of intravenous fluid (IVF) administration during cardiopulmonary resuscitation (CPR) is an unexplored factor that may improve cardiac output (CO) during CPR. The aim of this study was to determine the effect of IVF administration on CO and oxygenation during CPR.

Methods: This experimental animal study was performed in a critical care animal laboratory. Twenty-two Landrace-Yorkshire female piglets weighing 27-37 kg were anesthetized, intubated, and placed on positive pressure ventilation. Irreversible cardiac arrest was induced with bupivacaine. CPR was performed with a LUCAS 3 mechanical compression device. Pigs were randomized into IVF or no-IVF groups. Pigs in the IVF group were given 20 mL/kg of Plasma-Lyte (Baxter International, Deerfield, IL USA), infused from 15 to 35 min of CPR. CPR was maintained for 50 min with serial measurements of CO obtained using ultrasound dilution technology and partial pressure of oxygen (PaO2).

Results: A mixed-effects repeated measures analysis of variance was used to compare within-group, and between-group mean changes in CO and PaO2 over time. CO and PaO2 for the piglets were measured at 10-min intervals during the 50 min of CPR. CO was greater in the IVF compared with the control group at all time points during and after the infusion of the IVF. Mean PaO2 decreased with time; however, at no time was there a significant difference in PaO2 between the IVF and control groups.

Conclusions: Administration of IVF during CPR resulted in a significant increase in CO during CPR both during and after the IVF infusion. There was no statistically significant decrease in PaO2 between the IVF and control groups.

Keywords: Advanced cardiac life support; Basic cardiac life support; Cardiac arrest; Cardiac output; Out-of-hospital cardiac arrest.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram demonstrating summary of the experimental protocol
Fig. 2
Fig. 2
Mean values ± standard error of cardiac output for control and IVF groups as a function of time. As shown, p values demonstrate differences as a function of group and time after adjustment for baseline differences
Fig. 3
Fig. 3
Mean values ± standard error of partial pressure of oxygen for control and IVF groups as a function of time. As shown, p values demonstrate differences as a function of group and time after adjustment for baseline differences
See this image and copyright information in PMC

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