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. 2023 Mar 7:14:1091879.
doi: 10.3389/fphar.2023.1091879. eCollection 2023.

Natural products regulate mitochondrial function in cognitive dysfunction-A scoping review

Jinmei Tuo  1   2   3 , Yan Peng  1 , Yushuang Linghu  2 , Ming Tao  2 , Shiming Huang  2 , Zucai Xu  1   3
Affiliations

Natural products regulate mitochondrial function in cognitive dysfunction-A scoping review

Jinmei Tuo et al. Front Pharmacol. .

Abstract

Medicines from natural products can not only treat neurodegenerative diseases but also improve the cognitive dysfunction caused by treatments with western medicines. This study reviews the literature related to the regulation of mitochondrial participation in cognitive function by natural products. In this study, we focused on English articles in PubMed, Web of Science, and Google Scholar, from 15 October 2017, to 15 October 2022. Fourteen studies that followed the inclusion criteria were integrated, analyzed, and summarized. Several studies have shown that natural products can improve or reduce cognitive dysfunction by ameliorating mitochondrial dysfunction. These results suggest that natural products may serve as new therapeutic targets for neurodegenerative diseases.

Keywords: cognitive dysfunction; mitochondrial function; natural products; neurodegenerative diseases; scoping review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow chart of article identification.
FIGURE 2
FIGURE 2
Mitochondria are possibly involved in physiological and pathological mechanisms underlying cognition changes in neurodegeneration and aging. Mitochondria are multifunctional organelles with multiple functions, from bioenergy to cell signaling, and are signaling centers that induce transcription, proteomic, and posttranslational regulation mechanisms. The mitochondria play a central role in determining the fate of neural stem cells (NSCs). Mitochondria are also involved in protein assembly and regulation and mediate cell proliferation, differentiation, and death. Mitochondria can initiate a protective program called the mitochondrial unfolded protein response (UPRmt) and use this protective mechanism to maintain normal mitochondrial function (Liu et al., 2022b).
FIGURE 3
FIGURE 3
Mechanisms of natural products target mitochondrial function to improve neurodegeneration and cognitive impairment. Mitochondrial dysfunction results in the agglomeration of Aβ, tau phosphorylation, and agglomeration of Aβ and tau phosphorylation, further aggravating mitochondrial dysfunction, leading to neuronal loss or dysfunction, and ultimately inducing neurodegeneration and cognitive impairment. Natural products act on the mitochondria to improve tau phosphorylation and the agglomeration of amyloid β, neuronal loss, and dysfunction, thereby improving neurodegeneration and cognitive impairment.
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