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. 2022 Dec 22;4(1):2-18.
doi: 10.1016/j.xfre.2022.12.002. eCollection 2023 Mar.

The polycystic ovary syndrome: the first 150 years of study

Eli Y Adashi  1 , David Cibula  2   3 , Matthew Peterson  3 , Ricardo Azziz  4
Affiliations

The polycystic ovary syndrome: the first 150 years of study

Eli Y Adashi et al. F S Rep. .

Abstract

The communities of reproductive medicine and reproductive sciences have been witness to an enormous acceleration of interest in polycystic ovary syndrome (PCO) since the mid-19th century. Although progress has been increasingly palpable, the fundamentals of the etiology and pathophysiology of PCO remain as elusive as ever. Particularly lacking is a requisite understanding of events at the cellular and molecular levels. As we cross the millennial divide, it appears appropriate that an interim progress report be crafted. This treatise is attempting to meet this objective. What follows traces the chronology of the recorded history of PCO in 4 parts.

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Figures

Figure 1
Figure 1
Irving Freiler Stein, MD (1887–1976)
Figure 2
Figure 2
Michael Leo Leventhal, M.D. (1901–1971)
Figure 3
Figure 3
William Charles Keetel, M.D. (1911–1981)
Figure 4
Figure 4
Janet W. MacArthur, M.D. (1914–2006)
Figure 5
Figure 5
Francis M. Ingersoll, M.D. (1913–1991)
Figure 6
Figure 6
Robert Benjamin Greenblatt, M.D. (1906–1987)
Figure 7
Figure 7
Samuel S.C. Yen, M.D., Sc.D. (1927–2006)
Figure 8
Figure 8
Barnett Zumoff, M.D. (1926–2021)
Figure 9
Figure 9
James Robert Givens, M.D. (1930–2005)
Figure 10
Figure 10
William James (1842–1910)
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