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. 2022 Aug 23;26(1):21-25.
doi: 10.1002/ajum.12313. eCollection 2023 Feb.

The effect of cigarette smoking on first-trimester crown-rump length

Nicole Stamatopoulos  1   2 , Chuan Lu  3 , Samuel Vo  2 , Mercedes Espada Vaquero  1 , Mathew Leonardi  1   4 , George Condous  1
Affiliations

The effect of cigarette smoking on first-trimester crown-rump length

Nicole Stamatopoulos et al. Australas J Ultrasound Med. .

Abstract

Objectives: Does cigarette smoking impact the embryonic growth rate in the first trimester?

Methods: This is a retrospective multicentre observational study of 2912 pregnancies. Women who presented to the early pregnancy and perinatal ultrasound units between 2010 and 2019 were included in the study. The data collected included the following: smoking status, the crown-rump length (CRL) of the pregnancy at the first ultrasound that showed an embryonic heart rate, the gestation in days and the CRL at another ultrasound up to the nuchal translucency scan and the gestation in days. Additional demographic data included the following: age, weight, height, parity and mode of delivery.Of the 2912, complete smoking and demographic data were available for 657 pregnancies. One hundred and thirty-seven (26.3%) were smokers, and 520 (73.7%) were not. The rate of change of smokers vs non-smokers between two CRLs and two different days of gestation was calculated. The Wilcoxon rank sum test with continuity correction was used for statistical analysis.

Results: This gives a value of W = 31,940 and a P-value = 0.06. There is a slight shift in location for the smokers; however, it is not statistically significant. The insignificance may be due to the general large variance in growth rate.

Conclusion: The impact of cigarette smoking on embryonic growth rate detected by CRL in the first trimester is statistically insignificant.

Keywords: cigarette smoking; fetal growth; first‐trimester pregnancy; growth restriction.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram for patient inclusion criteria.
Figure 2
Figure 2
Box plot of non‐smoker vs. smoker.
Figure 3
Figure 3
Column chart of smoker vs. non‐smoker.
Figure 4
Figure 4
Line graph of smoker vs. non‐smoker.
See this image and copyright information in PMC

References

    1. Marom‐Haham L, Shulman A. Cigarette smoking and hormones. Curr Opin Obstet Gynecol 2016; 28: 230–5. - PubMed
    1. Crume T. Tobacco use during pregnancy. Clin Obstet Gynecol 2019; 62: 128–41. - PubMed
    1. Sandra Larsen C, Haavaldsen EK, Bjelland J, Dypvik AM, Jukic AE. Placental weight and birthweight: the relations with number of daily cigarettes and smoking cessation in pregnancy. A population study. J Epidemiol 2018; 47(4): 1141–50. - PMC - PubMed
    1. Brand JS, Gaillard R, West J, McEachan RRC, Wright J, Voerman E, et al. Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: findings from mendelian randomization and parental negative control studies. PLoS Med 2019; 16: e1002972. - PMC - PubMed
    1. Mook‐Kanamori DO, Steegers EAP, Eilers PH, Raat H, Hofman A, Jaddoe VWV. Risk factors and outcomes associated with first‐trimester fetal growth restriction. JAMA 2010; 303: 527–34. - PubMed