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Editorial
. 2023 Mar 7:14:1173906.
doi: 10.3389/fmicb.2023.1173906. eCollection 2023.

Editorial: Antibiotic potentiators against drug-resistant pathogens: Discovery, development and clinical applications

Bhabatosh Das  1 , Dinesh Mahajan  2 , Jasna Rakonjac  3
Affiliations
Editorial

Editorial: Antibiotic potentiators against drug-resistant pathogens: Discovery, development and clinical applications

Bhabatosh Das et al. Front Microbiol. .
No abstract available

Keywords: antibiotics; inhibitors; plasmids; potentiators; resistance.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram showing the potential targets of antibiotic potentiators. Potentiators may directly inhibit the activity of antibiotic resistance enzymes or reduce the activity of efflux pumps. Furthermore, by modulating the expression of antibiotic resistance genes (ARGs), potentiators may decrease their cellular level and resistance functions. Increasing membrane permeability may also aid antibiotics in killing resistant bacteria by reaching the threshold level. Several mobile genetic elements (MGEs) such as plasmids, integrative conjugative elements, and transposons are linked with ARGs. Thus, antibiotic resistance reversion is also possible by reducing the stability of such MGEs.
See this image and copyright information in PMC

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  • Editorial on the Research Topic Antibiotic potentiators against drug-resistant pathogens: Discovery, development and clinical applications

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