Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 7:14:1110824.
doi: 10.3389/fendo.2023.1110824. eCollection 2023.

The bidirectional relationship between endometriosis and microbiome

Cansu Uzuner  1 , Jason Mak  1 , Fatima El-Assaad  2 , George Condous  1
Affiliations
Review

The bidirectional relationship between endometriosis and microbiome

Cansu Uzuner et al. Front Endocrinol (Lausanne). .

Abstract

Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis via inflammatory pathways. The dysbiosis seen in endometriosis is thought to be both causative and a consequence of the pathogenesis. Gut, peritoneal fluid and female reproductive tract microbiota has been studied to understand if there are any microbiome signatures specific to endometriosis. New research on how to manipulate the microbiome for better detection and treatment of endometriosis is emerging.

Keywords: dysbiosis; endometriosis; immune response; inflammation; microbiome; microbiota.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Current interventions that have a potential in treatment of endometriosis. Created with BioRender.com.
See this image and copyright information in PMC

References

    1. Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, et al. . ESHRE guideline: endometriosis. Hum Reprod Open (2022) 2022(2):hoac009. doi: 10.1093/hropen/hoac009 - DOI - PMC - PubMed
    1. International working group of Aagl EE. Wes TC, Johnson NP, Petrozza J, Abrao MS, Einarsson JI, et al. . An international terminology for endometriosis, 2021. J Minim Invasive Gynecol (2021) 28(11):1849–59. doi: 10.1093/hropen/hoab029 - DOI - PubMed
    1. Leonardi M, Hicks C, El-Assaad F, El-Omar E, Condous G. Endometriosis and the microbiome: A systematic review. BJOG (2020) 127(2):239–49. doi: 10.1111/1471-0528.15916 - DOI - PubMed
    1. Darba J, Marsa A. Economic implications of endometriosis: A review. Pharmacoeconomics (2022) 40(12):1143–58. doi: 10.1007/s40273-022-01211-0 - DOI - PubMed
    1. Armour M, Lawson K, Wood A, Smith CA, Abbott J. The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: A national online survey. PloS One (2019) 14(10):e0223316. doi: 10.1371/journal.pone.0223316 - DOI - PMC - PubMed