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. 2023 Oct;19(10):4629-4640.
doi: 10.1002/alz.13048. Epub 2023 Mar 24.

Associations between dietary patterns and dementia-related neuroimaging markers

Jessica Samuelsson  1 , Anna Marseglia  2 , Olof Lindberg  2 , Eric Westman  2 , Joana B Pereira  2   3 , Sara Shams  4   5 , Silke Kern  1 , Felicia Ahlner  1 , Elisabet Rothenberg  6 , Ingmar Skoog  1   7 , Anna Zettergren  1
Affiliations

Associations between dietary patterns and dementia-related neuroimaging markers

Jessica Samuelsson et al. Alzheimers Dement. 2023 Oct.

Abstract

Background: The exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity.

Methods: Data were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical thickness, an Alzheimer's disease (AD) signature score, small vessel disease, and white matter microstructural integrity. Adjusted linear/ordinal regression analyses were performed.

Results: A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: -0.011; 95% confidence interval [CI]: -0.018 to -0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: -0.013; 95% CI: -0.024 to -0.001). A positive association was found between a Mediterranean-like dietary pattern and white matter microstructural integrity (Beta: 0.078; 95% CI: 0.002-0.154). No associations were found with a Western-like dietary pattern.

Discussion: Dietary patterns may impact brain integrity through neurodegenerative and vascular pathways.

Highlights: Certain dietary patterns were associated with dementia-related neuroimaging markers. A Mediterranean dietary pattern was positively associated with white matter microstructure. A high-protein and alcohol pattern was negatively associated with cortical thickness.

Keywords: Alzheimer's disease; dementia; dietary patterns; diffusion tensor imaging; magnetic resonance imaging; neuroimaging.

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References

REFERENCES

    1. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88-106. 10.1016/s1474-4422(18)30403-4
    1. Scarmeas N, Anastasiou CA, Yannakoulia M. Nutrition and prevention of cognitive impairment. Lancet Neurol. 2018;17:1006-15. 10.1016/s1474-4422(18)30338-7
    1. Jacobs DR, Jr., Gross MD, Tapsell LC. Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr. 2009;89:1543s-8s. 10.3945/ajcn.2009.26736B
    1. Solfrizzi V, Custodero C, Lozupone M, et al. Relationships of dietary patterns, foods, and micro- and macronutrients with Alzheimer's disease and late-life cognitive disorders: a systematic review. J Alzheimer's Dis. 2017;59:815-49. 10.3233/JAD-170248
    1. Andreu-Reinón ME, Chirlaque MD, Gavrila D, et al. Mediterranean diet and risk of Dementia and Alzheimer's disease in the EPIC-Spain Dementia Cohort Study. Nutrients. 2021;13(2):700. 10.3390/nu13020700

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